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Dehydroepiandrosterone sulphate and corticotropin levels are high in young male patients with conduct disorder: comparisons with growth factors, thyroid and gonadal hormones

Dmitrieva, and Oades, and Hauffa, and Eggers, (2001) Dehydroepiandrosterone sulphate and corticotropin levels are high in young male patients with conduct disorder: comparisons with growth factors, thyroid and gonadal hormones. [Journal (Paginated)]

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Abstract

Introduction: The biological concomitants of childhood conduct disorder (CD) have seldom been considered separate from those of hyperkinesis with which CD is often comorbid. CD predicts an increased likelihood of developing a personality disorder and is often associated with an antisocial outcome. Childhood CD may originate in a stressful upbringing in a dysfunctional family environment, and has been reported to be associated with unusual physical or sexual development and thyroid dysfunction. Methods: We therefore explored circulating levels of hormones from adrenal, gonadal and growth-hormone axes associated with stress, aggression and development in 28 CD patients and 13 age-matched healthy children (10-18 years old). Results: 1/ The CD group had higher levels of dehydroepiandrosterone sulphate (DHEA-S) and corticotropin (ACTH) and for those under 14 years of age there was more free triiodothyronine (fT3) in the circulation. 2/ There were no differences for gonadal hormones, and neither the levels of steroid hormones nor the ratings of maturity (early/late) were associated with aggression, as has been reported elsewhere. 3/ Smaller physical measures in CD children correlated with DHEA-S and growth factors (e.g. IGF-I): 4/ increased ACTH and fT3 correlated with restless-impulsive ratings, and DHEA-S with 'disruptive behaviour'. Conclusions: Imbalances in the adrenal and growth axes may indeed have neurotrophic repercussions in growth and development.

Item Type:Journal (Paginated)
Keywords:Child, Adolescent, Conduct Disorder, Hormones, Steroids, Peptides, Dehydroepiandrosterone, DHEA, DHEAS, corticotropin, ACTH, Growthm Maturation, Puberty, Androgen, Testosterone, Oestrogen, Luteinizing hormone, Follicular stimulating hormone, prolactin, Thyroid, Thyroid stimulating hormone, TSHtri-iodothyronine, fT3, fT4, IGF-1, IGFBP-3, Insulin-like growth factor, hyperactivity, impulsivity, aggression,
Subjects:Psychology > Developmental Psychology
Neuroscience > Neuroendocrinology
Neuroscience > Neuropsychiatry
Psychology > Psychobiology
ID Code:2018
Deposited By: OADES, Robert D.
Deposited On:11 Jan 2002
Last Modified:11 Mar 2011 08:54

References in Article

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1 Lahey BB, McBurnett K, Loeber R, et al: Psychobiology of conduct disorder; in Sholevar GP, (ed): Conduct disorders in children and adolescents: assessments and interventions. American Psychiatric Press, Washington DC, 1995.

2 Kratzer L, Hodgkins S: Adult outcomes of child conduct problems: a cohort study. J Abnorm Child Psychology 1997;25:65-81.

3 Bernstein DP, Cohen P, Skodol A, et al: Childhood antecedents of adolescent personality disorders. Am J Psychiatry 1996;153:907-913.

4 Lynskey MT, Fergusson DM: Childhood conduct problems, attention deficit behaviors and adolescent alcohol, tobacco & illicit drug use. J Abnorm Child Psychology 1995;23:281-302

5 Taylor EA, Chadwick O, Heptinsall E, et al: Hyperactivity and conduct problems as risk factors for adolescent development. J Am Acad Child Adolesc Psychiatry 1996;35:1213-1226

6 Gispen-de Wied C, Jansen LMC, Wynne HJ, et al: Differential effects of hydrocortisone and dexamethasone on cortisol suppression in a child psychiatric population. Psychoneuroendocrinology, 1998;23: 295-305.

7 Walker JL, Lahey BB, Russo MF, et al: Anxiety, inhibition and conduct disorder in children: I. relations to social impairment. J Am Acad Child Adolesc Psychiatry 1991;30:187-191.

8 Schulz KP, Halperin JM, Newcorn JH, et al: Plasma cortisol and aggression in boys with ADHD. J Am Acad Child Adolesc Psychiatry 1997;36:605-609.

9 Mattsson A, Schalling D, Olweus D, et al: Plasma testosterone, aggressive behavior and personality dimensions in young male delinquents. J Am Acad Child Adolesc Psychiatry 1980;19:476-490.

10 Scerbo AS, Kolko DJ: Salivary testosterone and cortisol in disruptive children: relationship to aggressive, hyperactive and internalizing behaviors. J Am Acad Child Adolesc Psychiatry 1994;33:1174-1184.

11 Oades RD: Frontal, temporal and lateralized brain function in children with attention-deficit hyperactivity-disorder (ADHD): a psychophysiological and neuropsychological viewpoint on development. Behav Brain Res 1998;94:83-95.

12 Hauser P, Soler R, Brucker-Davis F, et al: Thyroid hormones correlate with symptoms of hyperactivity but not inattention in attention-deficit hyperactivity disorder. Psychoneuroendocrinology 1997;22:107-114.

13 Elia J, Gulotta C, Rose SR, et al: Thyroid function and attention-deficit hyperactivity disorder. J Am Acad Child Adolesc Psychiatry 1994;33: 169-172.

14 Kretschmer E: Körperbau und Charakter. Springer-Verlag, Heidelberg, 1921.

15 Saugstad LF: The maturational theory of brain development and cerebral excitability in the multifactorially inherited manic-depressive psychosis and schizophrenia. Int J Psychophysiology 1994;18:189-203.

16 Goyette CH, Conners CK, Ulrich RF: Normative data on revised Conners parent and teacher rating scale. J Abnorm Child Psychology 1978;6:221-236.

17 Achenbach TL: Manual for the Child Behavior. Burlington, University of Vermont, 1991.

18 Tanner JM: Fetus into man: Physical growth from conception to maturity. Harvard University Press, Cambridge, MA, 1978.

19 Prader A, Largo RH, Molinari L, et al: Physical growth of Swiss children from birth to 20 years of age. First Zürich longitudinal study of growth and development. Helv Paediatr Acta 1989;52 [Suppl.]:1-125.

20 Marti-Carbonell MA, Darba S, Gerri A, et al: Hormones y agression. Arch Neurobiology 1992;55:162-174.

21 Virkkunen M, Linnoila M: Brain serotonin, type II alcoholism and impulsive violence. J Stud Alcohol 1993;11 (suppl):163-169.

22 Kruesi MJ, Hibbs ED, Zahn TP, et al: A 2-year prospective follow-up study of children and adolescents with disruptive behavior disorders. Arch Gen Psychiatry 1992;49:429-435.

23 Stoff DM, Pasatiempo AP, Yeung J, et al: Neuroendocrine responses to challenge with dl-fenfluramine and aggression in disruptive behavior disorders of children and adolescents. Psychiatry Res 1992;43:263-276.

24 Born J, Hansen K, Marshall, et al: Timing the end of nocturnal sleep. Nature 1999;397:29.

25 Lucki I: The spectrum of behavior influenced by serotonin. Biol Psychiatry 1998;44:151-162

26 Olweus D, Mattsson A, Schalling D, et al:. Circulating testosterone levels and aggression in adolescents males: A causal analysis. Psychosom Med 1988;50:261-272.

27 Gerra G, Avanzini P, Zaimovic A, et al: Neurotransmitter and endocrine modulation of aggressive behaviour and its components in normal humans. Behav Brain Res 1997;81:19-24

28 Constantino JN, Grosz D, Saenger P, et al: Testosterone and aggression in children. J Am Acad Child Adolesc Psychiatry 1993;32: 1217-1222.

29 van Goozen SHM, Matthys W, Cohen-Kettenis PT, et al: Adrenal androgens and aggression in conduct disorder prepubertal boys and normal controls. Biol Psychiatry 1998;43:156-158.

30 Dmitrieva TN: Deviant behavior in children and adolescents with psychopathological features of conduct disturbance:. Unpublished thesis, Moscow, National Scientific Centre for Psychiatry and Narcology, 1996.

31 Giusti G, Bassi F, Forti G, et al: Effects of prolactin on androgen secretion by the human adrenal cortex; in Robyn C, Harter M (ed): Progress in Prolactin Physiology and Pathology. Amsterdam, Elsevier, 1978, pp 293-303.

32 Strauss EB, Sands DE, Robinson AM, et al: Use of dehydroisoandrosterone in psychiatric treatment. Br Med J 1952;3:64.

33 Sands DE: Further studies on endocrine treatment in adolescence and early adult life. J Ment Sci 1954;100:211-219.

34 Hermida RC, Halberg F, del Pozo F: Chronobiologic pattern discrimination of plasma hormones notably DHEA-S and TSH, classified an expansive personality. Chronobiology 1985;12:105-135.

35 Oades RD, Schepker R: Serum gonadal steroid hormones in young schizophrenic patients. Psychoneuroendocrinology 1994;19:373-385.

36 Bologa L, Sharma J, Roberts E: Dehydroepiandrosterone and its sulfated derivative reduce neuronal death and enhance astrocytic differentiation in brain cell cultures. J Neurosci Res 1987;17:225-234.

37 Kimonides VG, Khatibi NH, Svendsen CN, et al: Dehydroepiandrosterone (DHEA) and DHEA-sulfate (DHEAS) protect hippocampal neurons against amino-acid-induced neurotoxicity. Proc Natl Acad Sci (USA) 1998;95:1852-1857.

38 Benbassat CA, Maki KC. Unterman TG: Circulating levels of insulin-like growth factor (IGF) binding protein-1 and -3 in aging men: relationships to insulin, glucose, IGF and dehydroepiandrosterone sulfate levels and anthropometric measures. J Clin Endocrinol Metabol 1997;82:1484-1491.

39 Deijen JB, de Boer H, Blok GJ, et al: Cognitive impairments and mood disturbances in growth hormone deficient men. Psychoneuroendocrinology 1996;21:313-322.

40 Spencer TJ, Biederman J, Harding M, et al: Growth deficits in ADHD children revisited: evidence for disorder-associated growth delays ? J Am Acad Child Adolesc Psychiatry 1996;35:460-1469.

41 Leo RJ, Batterman-Faunce JM, Pickhardt D, et al: Utility of thyroid function screening in adolescent psychiatric inpatients. J Am Acad Child Adolesc Psychiatry 1997;36:103-111.

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