creators_name: Dmitrieva, creators_name: Oades, creators_name: Hauffa, creators_name: Eggers, type: journalp datestamp: 2002-01-11 lastmod: 2011-03-11 08:54:52 metadata_visibility: show title: Dehydroepiandrosterone sulphate and corticotropin levels are high in young male patients with conduct disorder: comparisons with growth factors, thyroid and gonadal hormones ispublished: pub subjects: dev-psy subjects: neuro-endocrin subjects: neuro-psych subjects: psy-bio full_text_status: public keywords: Child, Adolescent, Conduct Disorder, Hormones, Steroids, Peptides, Dehydroepiandrosterone, DHEA, DHEAS, corticotropin, ACTH, Growthm Maturation, Puberty, Androgen, Testosterone, Oestrogen, Luteinizing hormone, Follicular stimulating hormone, prolactin, Thyroid, Thyroid stimulating hormone, TSHtri-iodothyronine, fT3, fT4, IGF-1, IGFBP-3, Insulin-like growth factor, hyperactivity, impulsivity, aggression, abstract: Introduction: The biological concomitants of childhood conduct disorder (CD) have seldom been considered separate from those of hyperkinesis with which CD is often comorbid. CD predicts an increased likelihood of developing a personality disorder and is often associated with an antisocial outcome. Childhood CD may originate in a stressful upbringing in a dysfunctional family environment, and has been reported to be associated with unusual physical or sexual development and thyroid dysfunction. Methods: We therefore explored circulating levels of hormones from adrenal, gonadal and growth-hormone axes associated with stress, aggression and development in 28 CD patients and 13 age-matched healthy children (10-18 years old). Results: 1/ The CD group had higher levels of dehydroepiandrosterone sulphate (DHEA-S) and corticotropin (ACTH) and for those under 14 years of age there was more free triiodothyronine (fT3) in the circulation. 2/ There were no differences for gonadal hormones, and neither the levels of steroid hormones nor the ratings of maturity (early/late) were associated with aggression, as has been reported elsewhere. 3/ Smaller physical measures in CD children correlated with DHEA-S and growth factors (e.g. IGF-I): 4/ increased ACTH and fT3 correlated with restless-impulsive ratings, and DHEA-S with 'disruptive behaviour'. Conclusions: Imbalances in the adrenal and growth axes may indeed have neurotrophic repercussions in growth and development. date: 2001 date_type: published publication: Neuropsychobiology volume: 43 publisher: Karger pagerange: 134-140 refereed: TRUE referencetext: 1 Lahey BB, McBurnett K, Loeber R, et al: Psychobiology of conduct disorder; in Sholevar GP, (ed): Conduct disorders in children and adolescents: assessments and interventions. American Psychiatric Press, Washington DC, 1995. 2 Kratzer L, Hodgkins S: Adult outcomes of child conduct problems: a cohort study. J Abnorm Child Psychology 1997;25:65-81. 3 Bernstein DP, Cohen P, Skodol A, et al: Childhood antecedents of adolescent personality disorders. Am J Psychiatry 1996;153:907-913. 4 Lynskey MT, Fergusson DM: Childhood conduct problems, attention deficit behaviors and adolescent alcohol, tobacco & illicit drug use. 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J Am Acad Child Adolesc Psychiatry 1997;36:103-111. citation: Dmitrieva, and Oades, and Hauffa, and Eggers, (2001) Dehydroepiandrosterone sulphate and corticotropin levels are high in young male patients with conduct disorder: comparisons with growth factors, thyroid and gonadal hormones. [Journal (Paginated)] document_url: http://cogprints.org/2018/2/CD-Neuropsychobiol-2001-art.pdf