"2018","Dehydroepiandrosterone sulphate and corticotropin levels are high in young male patients with conduct disorder: comparisons with growth factors, thyroid and gonadal hormones","Introduction: The biological concomitants of childhood conduct disorder (CD) have seldom been considered separate from those of hyperkinesis with which CD is often comorbid. CD predicts an increased likelihood of developing a personality disorder and is often associated with an antisocial outcome. Childhood CD may originate in a stressful upbringing in a dysfunctional family environment, and has been reported to be associated with unusual physical or sexual development and thyroid dysfunction.   Methods: We therefore explored circulating levels of hormones from adrenal, gonadal and growth-hormone axes associated with stress, aggression and development in 28 CD patients and 13 age-matched healthy children (10-18 years old).   Results:  1/ The CD group had higher levels of dehydroepiandrosterone sulphate (DHEA-S) and corticotropin (ACTH) and for those under 14 years of age there was more free triiodothyronine (fT3) in the circulation.  2/ There were no differences for gonadal hormones, and neither the levels of steroid hormones nor the ratings of maturity (early/late) were associated with aggression, as has been reported elsewhere. 3/ Smaller physical measures in CD children correlated with DHEA-S and growth factors (e.g. IGF-I): 4/ increased ACTH and fT3 correlated with restless-impulsive ratings, and DHEA-S with 'disruptive behaviour'.   Conclusions: Imbalances in the adrenal and growth axes may indeed have neurotrophic repercussions in growth and development.  ","http://cogprints.org/2018/","Dmitrieva,  and Oades,  and Hauffa,  and Eggers, ","UNSPECIFIED","       <span class=\"person_name\">Dmitrieva, </span> and <span class=\"person_name\">Oades, </span> and <span class=\"person_name\">Hauffa, </span> and <span class=\"person_name\">Eggers, </span>     (2001)  <a href=\"http://cogprints.org/2018/\"><em>Dehydroepiandrosterone sulphate and corticotropin levels are high in young male patients with conduct disorder: comparisons with growth factors, thyroid and gonadal hormones.</em></a>       [Journal (Paginated)]           ","","2001"