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Ingestion of amniotic fluid by postpartum rats enhances morphine antinociception without liability to maternal behavior

Tarapacki, J. A. and Piech, M. and Kristal, M. B. (1995) Ingestion of amniotic fluid by postpartum rats enhances morphine antinociception without liability to maternal behavior. [Journal (Paginated)]

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Abstract

Ingestion of amniotic fluid or placenta by rats has been shown to enhance opioid-mediated analgesia induced by morphine injection, foot shock, vaginal/cervical stimulation, or late pregnancy. The present study was designed to determine whether this mechanism might be a means of providing greater analgesia during the periparturitional period without contributing to the disruption of maternal behavior (measured primarily as retrieval) that can result from excessive opioid levels. Postpartum primiparous rats, injected with either 2 or 3 mg/kg morphine sulfate or vehicle and given orogastric infusions of either amniotic fluid or saline, were tested for maternal behavior. Pain threshold (determined by tail-flick latency test) in rats injected with 2 mg/kg morphine and infused with amniotic fluid was elevated to a level that did not differ significantly from that of a separate group of rats injected with 3 mg/kg morphine and infused with saline. This enhanced analgesia was not, however, accompanied by the significant disruption of maternal behavior found among the rats receiving the higher morphine dose.

Item Type:Journal (Paginated)
Keywords:parturition, POEF, maternal behavior, placentophagia, pain, antinociception, analgesia, amniotic fluid, opioids, morphine, pregnancy, postpartum, tail-flick latency
Subjects:Neuroscience > Behavioral Neuroscience
Neuroscience > Behavioral Neuroscience
Biology > Behavioral Biology
Psychology > Comparative Psychology
Neuroscience > Neurochemistry
Neuroscience > Neuroendocrinology
Neuroscience > Neuropharmacology
Psychology > Physiological Psychology
Psychology > Psychobiology
ID Code:68
Deposited By:Kristal, Mark B.
Deposited On:14 Nov 1998
Last Modified:11 Mar 2011 08:53

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