?url_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Adc&rft.title=Ingestion+of+amniotic+fluid+by+postpartum+rats+enhances+morphine+antinociception+without+liability+to+maternal+behavior&rft.creator=Tarapacki%2C+J.+A.&rft.creator=Piech%2C+M.&rft.creator=Kristal%2C+M.+B.&rft.subject=Behavioral+Neuroscience&rft.subject=Behavioral+Neuroscience&rft.subject=Behavioral+Biology&rft.subject=Comparative+Psychology&rft.subject=Neurochemistry&rft.subject=Neuroendocrinology&rft.subject=Neuropharmacology&rft.subject=Physiological+Psychology&rft.subject=Psychobiology&rft.description=Ingestion+of+amniotic+fluid+or+placenta+by+rats+has+been+shown+to+enhance+opioid-mediated+analgesia+induced+by+morphine+injection%2C+foot+shock%2C+vaginal%2Fcervical+stimulation%2C+or+late+pregnancy.+The+present+study+was+designed+to+determine+whether+this+mechanism+might+be+a+means+of+providing+greater+analgesia+during+the+periparturitional+period+without+contributing+to+the+disruption+of+maternal+behavior+(measured+primarily+as+retrieval)+that+can+result+from+excessive+opioid+levels.+Postpartum+primiparous+rats%2C+injected+with+either+2+or+3+mg%2Fkg+morphine+sulfate+or+vehicle+and+given+orogastric+infusions+of+either+amniotic+fluid+or+saline%2C+were+tested+for+maternal+behavior.+Pain+threshold+(determined+by+tail-flick+latency+test)+in+rats+injected+with+2+mg%2Fkg+morphine+and+infused+with+amniotic+fluid+was+elevated+to+a+level+that+did+not+differ+significantly+from+that+of+a+separate+group+of+rats+injected+with+3+mg%2Fkg+morphine+and+infused+with+saline.+This+enhanced+analgesia+was+not%2C+however%2C+accompanied+by+the+significant+disruption+of+maternal+behavior+found+among+the+rats+receiving+the+higher+morphine+dose.&rft.date=1995&rft.type=Journal+(Paginated)&rft.type=PeerReviewed&rft.format=text%2Fhtml&rft.identifier=http%3A%2F%2Fcogprints.org%2F68%2F1%2Fpiech.htm&rft.identifier=++Tarapacki%2C+J.+A.+and+Piech%2C+M.+and+Kristal%2C+M.+B.++(1995)+Ingestion+of+amniotic+fluid+by+postpartum+rats+enhances+morphine+antinociception+without+liability+to+maternal+behavior.++%5BJournal+(Paginated)%5D+++++&rft.relation=http%3A%2F%2Fcogprints.org%2F68%2F