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Nimesulide limits kainate-induced oxidative damage in the rat hippocampus

Candelario-Jalil, Eduardo and Ajamieh, Hussam and Sam, Susana and Martinez, Gregorio and Leon, Olga S. (2000) Nimesulide limits kainate-induced oxidative damage in the rat hippocampus. [Journal (Paginated)]

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Abstract

Kainate induces a marked expression of cyclooxygenase-2 after its systemic administration. Because cyclooxygenase-2 activity is associated to the production of reactive oxygen species, we investigated the effects of nimesulide, a selective cyclooxygenase-2 inhibitor, on kainate-induced in vivo oxidative damage in the rat hippocampus. A clinically relevant dose of nimesulide (6 mg/kg, i.p. ) was administered three times following kainate application (9 mg/kg, i.p.). After 24 h of kainate administration, the drastic decrease in hippocampal glutathione content and the significant increase in lipid peroxidation were attenuated in nimesulide-treated rats, suggesting that the induction of cyclooxygenase-2 is involved in kainate-mediated free radicals formation.

Item Type:Journal (Paginated)
Keywords:kainate; excitotoxicity; cyclooxygenase-2; nimesulide; oxidative stress; hippocampus
Subjects:Neuroscience > Neurochemistry
ID Code:5653
Deposited By:Candelario-Jalil, Dr Eduardo
Deposited On:20 Aug 2007
Last Modified:11 Mar 2011 08:56

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