?url_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Adc&rft.title=Nimesulide+limits+kainate-induced+oxidative+damage+in+the+rat+hippocampus&rft.creator=Candelario-Jalil%2C+Eduardo&rft.creator=Ajamieh%2C+Hussam&rft.creator=Sam%2C+Susana&rft.creator=Martinez%2C+Gregorio&rft.creator=Leon%2C+Olga+S.&rft.subject=Neurochemistry&rft.description=Kainate+induces+a+marked+expression+of+cyclooxygenase-2+after+its+systemic+administration.+Because+cyclooxygenase-2+activity+is+associated+to+the+production+of+reactive+oxygen+species%2C+we+investigated+the+effects+of+nimesulide%2C+a+selective+cyclooxygenase-2+inhibitor%2C+on+kainate-induced+in+vivo+oxidative+damage+in+the+rat+hippocampus.+A+clinically+relevant+dose+of+nimesulide+(6+mg%2Fkg%2C+i.p.+)+was+administered+three+times+following+kainate+application+(9+mg%2Fkg%2C+i.p.).+After+24+h+of+kainate+administration%2C+the+drastic+decrease+in+hippocampal+glutathione+content+and+the+significant+increase+in+lipid+peroxidation+were+attenuated+in+nimesulide-treated+rats%2C+suggesting+that+the+induction+of+cyclooxygenase-2+is+involved+in+kainate-mediated+free+radicals+formation.&rft.publisher=Elsevier&rft.date=2000-03&rft.type=Journal+(Paginated)&rft.type=PeerReviewed&rft.format=application%2Fpdf&rft.identifier=http%3A%2F%2Fcogprints.org%2F5653%2F1%2FKainate_nimesulide_Eur_J_Pharmacol_2000.pdf&rft.identifier=++Candelario-Jalil%2C+Eduardo+and+Ajamieh%2C+Hussam+and+Sam%2C+Susana+and+Martinez%2C+Gregorio+and+Leon%2C+Olga+S.++(2000)+Nimesulide+limits+kainate-induced+oxidative+damage+in+the+rat+hippocampus.++%5BJournal+(Paginated)%5D+++++&rft.relation=http%3A%2F%2Fcogprints.org%2F5653%2F