--- abstract: 'Xeroderma pigmentosum (XP) is a rare genetic disorder associated with multiple oculocutaneous and neurological manifestations. It occurs due to deficiency of the enzymes responsible for repairing ultraviolet radiation-induced DNA damage. Persistence of un-repaired DNA results in somatic mutations, leading to neoplasia of the skin and ocular surface. As this condition is rare, only isolated case reports of XP with ocular surface squamous neoplasia (OSSN) are found in literature. ' altloc: - http://www.ojhas.org/issue47/2013-3-15.html chapter: ~ commentary: ~ commref: ~ confdates: ~ conference: ~ confloc: ~ contact_email: ~ creators_id: - ~ - ~ - ~ - ajayrkamath@yahoo.com - ~ creators_name: - family: Nayak given: RR honourific: '' lineage: '' - family: Kamath given: GM honourific: '' lineage: '' - family: Kamath given: MM honourific: '' lineage: '' - family: Kamath given: AR honourific: '' lineage: '' - family: D'Souza given: S honourific: '' lineage: '' date: 2013-11-15 date_type: published datestamp: 2015-02-21 14:35:06 department: ~ dir: disk0/00/00/97/02 edit_lock_since: ~ edit_lock_until: 0 edit_lock_user: ~ editors_id: - Kakkilaya BS editors_name: - family: Kakkilaya given: Srinivas honourific: Dr lineage: '' eprint_status: archive eprintid: 9702 fileinfo: /9702/1.hassmallThumbnailVersion/2013-3-15.pdf;/9702/1/2013-3-15.pdf full_text_status: public importid: ~ institution: ~ isbn: ~ ispublished: pub issn: ~ item_issues_comment: [] item_issues_count: ~ item_issues_description: [] item_issues_id: [] item_issues_reported_by: [] item_issues_resolved_by: [] item_issues_status: [] item_issues_timestamp: [] item_issues_type: [] keywords: Ocular surface squamous neoplasia; Xeroderma pigmentosum lastmod: 2015-04-20 11:44:40 latitude: ~ longitude: ~ metadata_visibility: show note: ~ number: 3(15) pagerange: ~ pubdom: TRUE publication: Online Journal of Health and Allied Sciences publisher: Kakkilaya BS refereed: TRUE referencetext: "1.\tTrosko JE, Krause D, Isoun M. Sunlight-induced pyrimidine dimmers in human cells in vitro. Nature. 1970;228:358–359.\r\n2.\tKraemer KH, Lee MM, Scotto J. Xeroderma pigmentosum — cutaneous, ocular and neurologic abnormalities in 830 published cases. Arch Dermatol. 1987;123:241–250.\r\n3.\tLee GA, Hirst LW. Ocular surface squamous neoplasia. Surv Ophthalmol. 1995;39:429–450.\r\n4.\tGoyal JL, Rao VA, Srinivasan R, Agrawal K. Oculocutaneous manifestations in xeroderma pigmentosa. Br J Ophthalmol. 1994;78:295–297.\r\n5.\tBasti S, Macsai MS. Ocular surface squamous neoplasia: a review. Cornea. 2003;22:687–704.\r\n6.\tEric JC, Campbell RJ, Leisgang J. Conjunctival and corneal intraepithelial and invasive neoplasia. Ophthalmology. 1986;93:176–183.\r\n7.\tDivine RD, Anderson RL. Nitrous oxide cryotherapy for intraepithelial epithelioma of the conjunctiva. Arch Ophthalmol. 1983;101:782–786.\r\n8.\tFraunfelder FT, Wingfield D. Management of intraepithelial epitheliomas and squamous cell carcinomas. Am J Ophthalmol. 1983;95:359–363." relation_type: [] relation_uri: [] reportno: ~ rev_number: 10 series: ~ source: ~ status_changed: 2015-02-21 14:35:06 subjects: - OJHAS succeeds: ~ suggestions: ~ sword_depositor: ~ sword_slug: ~ thesistype: ~ title: Ocular Surface Squamous Neoplasia in Xeroderma Pigmentosum type: journale userid: 4338 volume: 12