creators_name: Tan, Uner creators_name: Tamam, Yusuf creators_name: Karaca, Sibel creators_name: Tan, Meliha creators_id: unertan37@yahoo.com creators_id: sibelemre2003@yahoo.com creators_id: Meliha_Tan@yahoo.com editors_name: Tan, Uner editors_id: 33098227240 type: bookchapter datestamp: 2013-05-04 23:24:57 lastmod: 2013-05-04 23:24:57 metadata_visibility: show title: Üner Tan Syndrome: Review and Emergence of Human Quadrupedalism in Self-Organization, Attractors and Evolutionary Perspectives ispublished: pub subjects: behav-neuro-sci subjects: neuro-neu subjects: neuro-physio subjects: neuro-psy full_text_status: public keywords: Uner Tan syndrome, human quadrupedalism, mental retardation, speech, ataxia, genetics, cognition, locomotion, tetrapods, diagonal-sequence quadrupedalism, Darwinian medicine, atavism, complex systems, self-organization, central pattern generator, evolution in reverse, evolution, human abstract: The first man reported in the world literature exhibiting habitual quadrupedal locomotion was discovered by a British traveler and writer on the famous Baghdat road near Havsa/Samsun on the middle Black-Sea coast of Turkey (Childs, 1917). Interestingly, no single case with human quadrupedalism was reported in the scientific literature after Child's first description in 1917 until the first report on the Uner Tan syndrome (UTS: quadrupedalism, mental retardation, and impaired speech or no speech)in 2005 (Tan, 2005, 2006). Between 2005 and 2010, 10 families exhibiting the syndrome were discovered in Turkey with 33 cases: 14 women (42.4%) and 19 men (57.6%). Including a few cases from other countries, there were 25 men (64.1%)and 14 women (35.9%). The number of men significantly exceeded the number of women (p < .05). Genetics alone did not seem to be informative for the origins of many syndromes, including the Uner Tan syndrome. From the viewpoint of dynamical systems theory, there may not be a single factor including the neural and/or genetic codes that predetermines the emergence of the human quadrupedalism.Rather, it may involve a self-organization process, consisting of many decentralized and local interactions among neuronal, genetic, and environmental subsystems. The most remarkable characteristic of the UTS, the diagonal-sequence quadrupedalism is well developed in primates. The evolutionarily advantage of this gait is not known. However, there seems to be an evolutionarily advantage of this type of locomotion for primate evolution, with regard to the emergence of complex neural circuits with related highly complex structures. Namely, only primates with diagonal-sequence quadrupedal locomotion followed an evolution favoring larger brains, highly developed cognitive abilities with hand skills, and language, with erect posture and bipedal locomotion, creating the unity of human being. It was suggested that UTS may be considered a further example for Darwinian diseases, which may be associated with an evolutionary understanding of the disorders using evolutionary principles, such as the natural selection. On the other hand, the human quadrupedalism was proposed to be a phenotypic example of evolution of reverse, i.e., the reacquisition by derived populations of the same character states as those of ancestor populations. It was also suggested that the emergence of the human quadrupedalism may be related to self-organizing processes occurring in complex systems, which select or attract one preferred behavioral state or locomotor trait out of many possible attractor states. Concerning the locomotor patterns, the dynamical systems in brain and body of the developing child may prefer some kind of locomotion, according to interactions of the internal components and the environmental conditions, without a direct role of any causative factor(s), such as genetic or neural codes, consistent with the concept of self-organization, suggesting no single element may have a causal priority. date: 2012 date_type: published publication: Üner Tan Syndrome: Review and Emergence of Human Quadrupedalism in Self-Organization, publisher: InTech Croatia pagerange: 1-44 refereed: TRUE referencetext: Abed, R.T., & Pauw, K.W. (1998). An evolutionary hypothesis for obsessive compulsive disorder : a-psychological immune system. Behav Neurol, Vol. 11(4), pp. 245-250. Akpinar S. (2009). In restless legs syndrome, the neural substrates of the sensorimotor symptoms are also normally involved in upright standing posture and bipedal walking. Med Hypothesis, Vol. 73, pp. 169-176. Andermann, F., Andermann, E. et. al. (1999). History of Joubert syndrome and a 30-year follow-up of the original proband. J Child Neurol, Vol. 14, pp. 565-569. Arguello, F. (2011). Atavistic Metamorphosis A New and Logical Explanation for the origin and biological Nature of Cancer. Lexington, KY, USA. Baala, L., Romano, S., et al. (2007). The Meckel-Gruber syndrome gene, MKS3, is mutated in Joubert syndrome. Am J Hum Genet, Vol. 80, pp. 186-194. Bailey K.G. (1978). The concept of phylogenetic regression. J Am Acad Psychoanal, Vol. 6, pp. 5-35. Bal, P. (2001). The self-made tapestry : pattern formation in nature, Oxford: Oxford University Press. Bar, I., et al. (2000). The evolution of cortical development. An hypothesis based on the role of the reelin signaling pathway. Trends Neurosci, Vol. 23, pp. 633-638. Bar-Yam, Y. (1997). Dynamics of complex systems. Perseus Books, Reading Massachusetts, USA. Bekpen, C., Marques-Bonet, T., et al. (2009). Death and resurrection of the human IRGM gene. PLoS Genet, Vol. 5 : e1000403. Bomar, J.M., Benke, P.J., et al. (2003). Mutations in a novel gene encoding a CRAL-TRIO domain cause human Cayman ataxia and ataxia/dystonia in the jittery mouse. Nat Gen, Vol. 35, pp. 264-269. Bornholdt, S., & Rohl, T. (2003)ç Self-organized critical neural networks. Phys Rev E Stat Nonlin Soft Matter Phys, Vol. 67, pp. 066118. Boycott, K.M., Bonnemann, C., et al. (2009). Mutations in VLDLR as a cause for autosomal recessive cerebellar ataxia with mental retardation (disequilibrium syndrome). J Child Neurol, Vol. 24(10), pp. 1310-1315. Boycott, K.M., Flavelle, S., et al. (2005). Homozygous deletion of the very low density lipoprotein receptor gene causes autosomal recessive cerebellar hypoplasia with cerebral gyral simplification. Am J Genet, Vol. 77(3), pp. 477-483. Braddock, B.A. (2006). Oromotor and communication findings in Joubert syndrome: further evidence of multisystem apraxia. J Child Neurol, Vol. 21, pp. 1-3. Braddock, S.R., Henley, K.M., et al. (2007). The face of Joubert syndrome: a study of dysmorphology and anthropometry. Am J Med Genet, Vol. 143A, pp. 3235-3242. Brown, T.G. (1911). The intrinsic factors in the cat of progression in the mammal. Proc R Soc Lond, Vol.B84, pp.308-319. Brown, T.G. (1912). The factors in rhythmic activity of the nervous system. Proc R Soc London Ser, Vol.B85, pp.278-289. Brown, L., Mueller, M., et al. (1984). A non-progressive cerebellar ataxia on Grand Cayman Island. Neurology, Vol. 34, pp. 271-273. Brunet, M., Guy, F., et al. (2002). A new hominid from the upper Miocene of Chad, central Africa. Nature, Vol. 18(6894), pp. 145-151. 36 Latest Findings in Intellectual and Developmental Disabilities Research Brüne, M. (2004). Schizophrenia–an evolutionary enigma. Neurosci Biobehav Rev, Vol.28, pp. 41-53. Bujo, H., Hermann, M., et al. (1994). Chicken oocyte growth is mediated by an eight ligand binding repeat member of the LDL receptor family. The EMBO J, Vol. 13(21), pp. 5165-5175. Burns, J.K. (2004). An evolutionary theory of schizophrenia: cortical connectivity, metarepresentation ad the social brain. Behav Brain Sci, Vol. 27(6), pp. 831-885. Camazine, S., Deneubourg, J.-L., et al. (2002). Self-organization in Biological systems. Princeton University Press. Cartmill, M., Lemelin, P., & Schmitt, D.O. (2002). Support polygons and symmetrical gaits in mammals. Zool J Linn Soc, Vol. 136, pp.401-420. Castillo, H.A., Cravo, R.M. et al. (2009). Insights into the organization of dorsal spinal cord pathways from an evolutionarily conserved raldh2 intronic enhancer. Development, Vol. 137, pp. 507-518. Castle, W.E. (1906). The origin of a polydactylous race of guinea-pigs. Publ Carnegie Inst Washington, Vol. 49, pp. 15-29. Chan, B.W., et al. (2002). Maternal diabetes increases the risk of caudal regression caused by retinoic acid. Diabetes, Vol. 51, pp. 2811-2816. Childs, W.J. (1917). Across Asia Minor on Foot. William Blackwood and Sons, Edinburgh and London. Clack, J. (2011). www.plantir.fsnet.co.uk/acanthostega.htm. Clarac, E. (2008). Some historical reflections on the neural control of locomotion. Brain Res, Vol.57, pp.13-21. Cohen, A.H. (1992). The role of hierarchial control in the evolution of central pattern generators. Brain Behav Evol, Vol.40, pp.112-124. Daeschler, E.B., Shubin, N.H., et al. (2006). A devonian tetrapod-like fish and the evolution of the tetrapod body plan. Nature, Vol. 440, pp.757-763. Dart, R.A. (1925). Australopethicus africanus, the man-ape of South Africa. Nature, Vol. 115, pp. 195-199. Day, M.H. & Stringer, C.B. (1982). L’Homo erectus et la place de l’homme de Tautavel permi les hominides fossiles. De Lumley, M.A. (Ed.). Centre National de la Recherche Scientifique, Nice, France, pp. 814-846. Demes, B.,Larson, S.G., et al. (1994). The kinetics of primate quadrupedalism: “hindlimb drive” reconsidered. J Hum Evol, Vol. 26, pp. 353-374. Dietz, V. (2002). Human bipeds use quadrupedal coordination? Trends Neurosci, Vol.25, pp.462-467. Dixon-Salazar, T., Silhavy, J.L., et al. (2004). Mutations in the AHI1 gene, encoding jouberin, cause Joubert syndrome with cortical polymicrogyria. Am J Hum Genet, Vol. 75: pp. 979-987. Dobrescu, R., & Purcarea, V.L. (2011). Emergence, self-organization and morphogenesis in biological systems. J Med Life, Vol. 4, pp. 82-90. Dollo, L. (1893). Les lois de l’évolution. Bull Belge de la Societé de Géologie, de Paléontologie, et Hydrologie, Vol. 8, pp. 164-166. Donker, S.F., Beek, P.J., et al. (2001). Coordination between arm and leg movements during locomotion. J Mot Behav, Vol. 33, pp. 86-102. Üner Tan Syndrome: Review and Emergence of 37 Human Quadrupedalism in Self-Organization, Attractors and Evolutionary Perspectives Downey G. (2010a). Human, Quadruped: Uner Tan syndrome, part 1. Retrieved from http://blogs.plos.org/neuroanthropology/2010/09/03/human-quadruped-uner tan syndrome-part-1/. Downey G. (2010b). 2 legs good, 4 legs better: Uner Tan syndrome, part 2, Retrieved from http://blogs.plos.org/neuroanthropology/2010/09/05/2-legs-good-4-legs-better uner tan-syndrome-part-2/. Dubrow, T.J., Wackym, P.A., & Lesavoy, M.A. (1988). Detailing the human tail. Ann Plast Surg, Vol. 20, pp. 340-344. Duysens, J., Van de Crommert, W.A.A. (1998). Neural control of locomotion; Part 1: the central pattern generator from cats and humans. Gait and Posture, Vol.7, pp.131-141. Eidelberg, e. (1981). Consequences of spinal cord lesions upon motor function, with special reference to locomotor activity. Prog Neurobiol, Vol.17, pp.185-202. Eskenazi, B.R., Wilson-Rich, N.S., & Starks, P.T. (2007). A Darwinian approach to Huntington’s disease: subtle health benefits of a neurological disorder. Med Hypothesis, Vol. 69, pp. 1183-1189. Ewing, B., & Green, P. Analysis of expressed sequence tags indicates 35.000 genes. Nat Genet, Vol.25, pp. 232-234. Filler, A. (2010). Redifining the word “human”—Do some apes have human ancestors? 24 (http://blog.oup.com/2007/12/human/) Accessed 3 march 2010. Fink, J.K., Hedera, P. (1999). Hereditary spastic paraplegia: genetic heterogeneity and genotype-phenotype correlation. Sem Neurol, Vol. 19, pp. 301-309. Fiscella, G.N., & Smith, F.H. (2006). Ontogenetic study of the supraorbital region in modern humans: a longitudinal test of the spatial model. Anthropol Anz, Vol. 64(2), pp. 147- 160. Folstein, M.F., Folstein, S.E., & McHugh, P.R. (1975). “Mini-mental state”. A practical method for grading the cognitive state of patients for the clinician. J Psychiat Res, Vol. 12(3), pp.189-198. Forssberg, H. (1985). Ontogeny of human locomotor control. 1. Infant stepping, supported locomotion and transition to independent locomotion. Exp Brain Res, Vol.57(3), pp.480-493. Galis, F., Arntzen, J.W., & Lande, T. (2010). Dollo’s law and the irreversibility of digit loss in Bachia. Evol, Vol. 64(8), pp. 2466-2476. Garber K.B. (2008). Editor’s corner: This month in genetics; VLDLR receptor stands tall. Am Hum Gen, Vol. 82, p. 807. Ghika, J. (2008). Paleoneurology: neurodegenerative diseases are age-related diseases of specific brain regions recently developed by homo sapiens. Med Hypotheses, Vol. 71, pp. 788-801. Glass, H.C., Boycott, K.M., et al. (2005). Autosomal recessive cerebellar hypoplasia in the Hutterite population. Dev Med Child Neurol, Vol. 47, pp. 691-695. Goudot, P. (2002). The mandibular canal of the “old man” of Cro-Magnon: anatomical- radiological study. J Crnio-Maxillofac Surg, Vol. 30, pp. 213-218. Grillner, S., & Wallen, P. (1985). Central pattern generators for locomotion, with special reference to vertebrates. Ann Rev Neurosci, Vol.8, pp.233-261. Groves, C. (1999). Austra lopithecus garki: a new-found link? Rep of Nat Cent Sci Edu, May/June, Vol. 19, No. 3. 38 Latest Findings in Intellectual and Developmental Disabilities Research Gulsuner, S., Tekinay, A.B., et al. (2011). Homozygosity mapping and targeted genomic sequencing reveal the gene responsible for cerebellar hypoplasia and quadrupedal locomotion in a consanguineous kindred. Genome Res, doi 10.1101/gr.126110.111. Hagberg, B., Sanner, G., & Steen, M. (1972). The dysequilibrium syndrome in cerebral palsy. Acta Paediat, Vol. 61, pp. 1-63. Hall, B.K. (1984). Developmental mechanisms underlying the formation of atavism. Biol Rev, Vol. 59, pp. 89-124. Harris, M.P., Hasso, S.M., et al. (2006). The development of archosaurian first- generation teeth in a chicken mutant. Curr Biol, Vol.16(4), pp.371-377. Hayakawa, Y., Itoh, M., et al. (2007). Expression and localization of Cayman ataxia-related protein, Caytaxin, is regulated in a developmental- and spatial-dependent manner. Brain Res, Vol. 19, pp. 100-109. Held L.I. (2009). Quirks of Human Anatomy; Cambridge University Press: Cambridge. Hiebert, A., Jonckheere, E., et al. (2006). Visualization of a stationary CPG-revealing spinal wave. Stud Health Technol Inform, Vol.119, pp.198-200. Hildebrand, M. (1966). Analysis of the symmetrical gaits of tetrapods. Folia Biotheor, pp. 1-22. Hildebrand, M. (1967). Symmetrical gaits of primates. Am J Phys Anthropol, Vol. 26, pp. 119- 130. Hildebrand, M. (1968). Symmetrical gait of dogs in relation to body build. J Morphol, Vol. 124, pp. 353-360. Hooper, S.L. (2000). Central pattern generators. Curr Biol, Vol.10, R176. Hughes, G.M., & Wiersma, C.A.G. (1960). The co-ordination of swimmeret movements in the crayfish, Procambarus clarkia. J Exp Biol, Vol.37, pp.657-670. Garcias, G.deL., & Martino, MdaG. (2007). A Brazilian family with quadrupedal gait, severe mental retardation, coarse facial characteristics, and hirsutism. Int J Neurosci, Vol. 117, pp. 927-933. Harris, M.P., Hasso, S.M., et al. (2006). The development of Archosaurian first-generation teeth in a chicken mutant. Curr Biol, Vol. 21, pp. 371-377. Inglis, J., & Lawson, J.S. (1981). Sex differences in the effects of unilateral brain damage on intelligence. Science, Vol.212, pp.693-695. Jen, J.C., Lee, H., et al., (2006). Genetic heterogeneity of autosomal dominant nonprogressive congenital ataxia. Neurol, Vol. 67, pp. 1704-1706. Johnson, W.G., Murphy, M. et al. (1978). Recessive congenital cerebellar disorder in a genetic isolate: CPD Type VII? Neurology, Vol. 28, pp. 351-352. Joubert, M., Eisenring, J.J., et al. (1969). Familial agenesis of the cerebellar vermis. A syndrome of episodic hyperpnea, abnormal eye movements, ataxia, and retardation. Neurol, Vol. 19, pp. 813-825. Kamm, K., Thelen, E Kelso, J.A.S. (1995). Dynamic patterns. A Bradford Book, The MIT Press, England. Kimura, T. (1985). Bipedal and quadrupedal walking of primates: comparative dynamics. In Kondo S, editor. Primate morpho-physiology, locomotor analyses and human bipedalism. Tokyo: University of Tokyo Press. pp. 81-105. Kimura, T., Okada, M., & Ishida, H. (1979). Kinesiological chracteristics of primate walking: its significance in human walking. In: Morbek ME, Preuschoft H, & Gomberg N, editors. Environment, behavior, and morphology: dynamic interactions in primates. New York: G. Fischer. pp. 297-311. Üner Tan Syndrome: Review and Emergence of 39 Human Quadrupedalism in Self-Organization, Attractors and Evolutionary Perspectives Kupczik, K., Dobson, C.A., et al. (2009). Masticatory loading and bone adaptation in the supraorbital torus of developing macaques. Am J Phys Anthropol, Vol. 139, pp. 193-203. Larson, S.G. (1998). Unique aspects of quadrupedal locomotion in nonhuman primates. In: Strasser E, et al., editors. Primate locomotion: recent advances. New York: Plenum Press. pp. 157-174. Larson, S.G., & Stern Jr., J.T. (1987). EMG of chimpanzee shoulder muscles during knuckle- walking: problems of terrestrial locomotion in a suspensory adapted primate. J Zool Lond, Vol. 2121, pp. 629-655. Le Fanu J. (2009). Why us? How science rediscovered the mystery of ourselves. Panthoen Books, New York. P. 320. Lemelin, P., Schmitt, D., & Cartmill, M. (2003). Footfall patterns and interlimb co-ordination in opossums (family Didelphidae): evidence for the evolution of diagonal sequence walking gaits in primates. J Zool Lond, Vol. 260, pp. 423-429. Lewis, E.B. (1987). Gene complex controlling segmentation in Drosophila. Nature, Vol. 276, pp. 565-570. Lieberman, D.E., McBratney, B.M., & Krovitz, G. (2002). The evolution and development of cranial from in Homo sapiens. PNAS, Vol. 99, pp. 1134-1139. McGlone, J. (1977). Sex differences in the cerebral organization of verbal functions in patients with unilateral brain lesions. Brain, Vol. 100, pp. 775-793. Melberg, A., Öerlén, H., et al. (2011). Re-evaluation of the disequilibrium syndrome. Ann Neurol Scand, Vol. 23, pp. 28-33. Meldrum, D.J. (1991). Kinematics of the cercopithecine foot on arboreal and terrestrial substrates with implications for the interpretation of hominid terrestrial adaptations. Am J Phys Anthropol, Vol. 84, pp. 273-289. Moheb, L.A., Tzschach, A., et al. (2008). Identification of a nonsense mutation in the very low-density lipoprotein receptor gene (VLDLR) in an Iranian family with disequilibrium syndrome. Eur J Hum Genet, Vol. 16, pp. 270-273. Mungas, D. (1991). In-office mental status testing: a practical guide. Geriatrics, Vol. 46(7), pp. 54-58. Muybridge, E. (1887). Animal Locomotion. Dover, New York, NY. Muybridge E. (1901). The Human Figure in Motion. London: Chapman & Hall., Ltd. Nesse, R.M. (2001). How is Darwinian medicine useful? West J Med, Vol. 174, pp. 358-360. Nesse, R.M.,& Stearns, S., Omenn, G. (2006). Medicine needs evolution. Science, Vol. 311, p. 1071. Nesse, R.M., & Williams, G.C. (1994). Why we get sick? The new science of Darwinian medicine. New York, NY: Vintage. Nystuen, A., Benke, P.J., et al. (1996). A cerebellar ataxia locus identified by DNA pooling to search for linkage disequilibrium in an isolated population from the Cayman Islands. Hum Mol Genet, Vol. 5(4), pp. 525-531. Niedzwiedzki, G., Szrek, P., et al. (2010). Tetrapod trackways from the early Middle Devonian period of Poland. Nature, Vol. 463, pp. 43-48. Ohanson, D.C., Asao, F.T. et al. (1987). New partial skeleton of homo habilis from Olduvai Gorge, Tanzania. Nature, Vol. 327(6119), pp. 205-209. 40 Latest Findings in Intellectual and Developmental Disabilities Research Oudeyer, P-Y. (2006). Self-organization: complex dynamical systems in the evolution of speech. In: Self-organization in the evolution of speech, P-Y. Oudeyer (ed.). Oxford studies in the evolution of language 6. Oxforf University Press. Owen, R. (1855). Of the anthropoid apes and their relation to man. Royal Institution og Great Britain, Proceedings 1854-1858 (London), 3:26. Ozcelik, T., Akarsu, N., Uz, E., et al. (2008a). Mutations in the very low density lipoprotein receptor VLDLR cause cerebellar hypoplasia and quadrupedal locomotion in humans. Proc Natl Acad Sci USA, Vol. 105, pp. 4232-4236. Ozcelik, T., Akarsu, N., et al. (2008b). Genetic heterogeneity of cerebellar hypoplasia with quadrupedal locomotion. Proc Natl Acad Sci USA, Vol. 105, pp.E32-E33. Palau, F., & Espinos, C. (2006). Autosomal recessive cerebellar ataxias. Orphanet J Rare Dis; 1:47 doi:10.1186/1750-1172-1-47. Parisi, M.A., Bennett, C.L., et al. (2004). The NPHP1 gene deletion associated with juvenile nephronophtisis is present in a subset of individuals with Joubert syndrome. Am J Hum Genet, Vol. 75, pp. 82-91. Pearlson, G.D., & Folley, B.S. (2008). Schizophrenia, psychiatric genetics, and Darwinian psychiatry: an evolutionary framework. Schizophr Bull, Vol. 34(4), pp. 722-733. Porter, M.L., % Crandall, K.A. (2003). Lost along the way: the significance of evolution in reverse. Trends Ecol Evol, Vol. 18, pp. 541-547. Prasun, P., Pradhan, M., & Agarwal, S. (2007). One gene, many phenotypes. J Postgrad Med, Vol. 53, pp. 57-61. Preuschoft, H. (2004). Mechanisms for the acquisition of habitual bipedality: are there biomechanical reasons for the acquisition of upright bipedal posture. J Anat, Vol. 204, pp. 363-384. Pribut, S.M. (2010) Quadrupedal Human Gait. http://www.drpribut.com/blog/index.php/2010/07/quadripedal-human-gait/ Prost, J.H. (1969). A replication study on monkey gaits. Am J Anthropol, Vol. 30, pp. 203-208. Prost, J.H., & Sussman, J.H. (1969). Monkey locomotion on inclined surfaces. Am J Phys Anthropol, Vol. 31, pp. 53-58. Rapoport, S.I. (1988). Brain evolution and Alzheimer’s disease. Rev Neurol,Vol. 144, p. 7990. Raichlen, D.A., Pontzer, H., et al. (2008). Understanding hind limb weight support in chimpanzees with implications for the evolution of primate locomotion. Am J Phys Anthropol, Vol. 138, pp. 395-402. Reilly, S.M., McElroy, E.J., et al. (2006). Tuataras and salamanders show that walking and running are ancient features of tetrapod locomotion. Proc R Soc B, Vol. 273, pp. 1563-1568. Reynolds, T.R. (1985). Stresses on the limbs of quadrupedal primates. Am J Phys Anthropol, Vol. 67, pp. 101-116. Reynolds, T.R. (2005). Stresses on the limbs of quadrupedal primates. Am J Phy Anthro, Vol. 67, pp. 351-362. Richmond, B. G. & Strait, D. S. (2000). Evidence that humans evolved from a knuckle- walking ancestor. Nature, Vol. 404, pp. 382–385. Rollinson, J., & Martin, R.D. (1981). Comparative aspects of primate locomotion with special reference to arboreal cercopithecines. Symp Zool Soc Lond, Vol. 48, pp. 377-427. Rose, M.D. (1973). Quadrupedalism in primates. Primates, Vol. 14, pp. 337-357. Üner Tan Syndrome: Review and Emergence of 41 Human Quadrupedalism in Self-Organization, Attractors and Evolutionary Perspectives Rosenbaum, D.A., & Saltzman, E. (1984). A motor-program editor. In W. Prinz and A.Sanders (Eds.), Cognition and motor processes (pp.51-61). Heidelberg : Springer. Rossignol, S., & Dubuc, R. (1994). Spinal pattern generation. Curr Opin Neurobiol, Vol.4, pp.894-902. Russell, M.D. (1985). The supraorbital torus: “a most remarkable peculiarity.” Anthropol, Vol. 26(3), pp. 337-360. Saraiva, J.M., & Baraitser, M. (1992). Joubert syndrome: a review. Am J Med Genet, Vol. 43, pp. 726-731. Sayer, J.A., Otto, E.A., et al. (2006). The centrosomal protein nephrocystin-6 is mutated in Joubert syndrome and activates transcription factor ATF4. Nat Genet, Vol. 38, pp. 674-681. Schmitt M.D. (1994). Forelimb mechanics as a function of substrate type during quadrupedalism in two anthropoid primates. J Hum Evol, Vol. 26, pp. 441-457. Schmitt, D. (2003). Insights into the evolution of human bipedalism from experimental studies of humans and other primates. J Exp Biol, Vol. 206, pp. 1437-1448. Schmitt, D., & Hanna, J.B. (2004). Substrate alters forelimb and hind limb peak force ratios in primates. J Hum Evol, Vol. 46, pp. 239-254. Schmitt, D., & Lemelin, P. (2002). Origins of primate locomotion : gait mechanics of the woolly opossum. Am J Phys Anthropol, Vol. 118, pp. 231-238. Schurig, V., Oram, A.V., & Bowen, P. (1981). Nonprogressive cerebellar disorder with mental retardation and autosomal recessive inheritance in Hutterites. Am J Med Genet, Vol. 8, pp. 43-53. Scorza, F.A., Cysneiros, R.M., et. al. (2009). From Galapagos to the labs: Darwinian medicine and epilepsy today. Epilelpsy Behav, Vol. 16, pp. 388-390. Shapiro,L.J., & Jungers, W.L. (1994). Electromyography of back muscles during quadrupedal and bipedal walking in primates. Am J Phys Anthropol, Vol.93, pp.491-504. Shapiro, L., & Raichlen, D. (2005). Lateral sequence walking in infant Papio cynocephalus: implications for the evolution of diagonal sequence walking in primates. Am J Phys Anthropol, Vol. 126, pp. 205-213. Shapiro, L.J., & Raichlen, D.A. (2006). Limb proportions and the ontogeny of quadrupedal walking in infant baboons (Papio cynocephalus). J Zool, Vol. 269, pp. 191-203. Shik, M.L., Orlovsky, G.N. (1976). Neurophysiology of locomotor automatism. Physiol Rev, Vol.55, pp.465-501. Shik, M.L., Severin, F.V., & Orlovsky, G.N. (1966). Control of walking and running by means of electrical stimulation of the mid-brain. Biophysics, Vol.11, pp.756-765. Shubin, N.H., Daeschler, E.B., & Jenkins, F.A. (2006). The pectoral fin of Tiktaalik and the origin of the tetrapod limb. Nature, Vol. 440, pp. 764-771. Siler, C.D., & Brown, R.M. (2011). Evidence for repeated acquisition and loss of complex body-form characters in an insular clade of Southeast Asian semi-fossorial skinks. Evolotion, Vol.65(9), pp.2641-2663. Skar, J. (2003). Introduction: self-organization as an actual theme. Phil Trans R Soc Lond A, Vol. 361, pp. 1049-1056 Skoyles, J.R. (2009). The paleoanthropological implications of neural plasticity. CogPrints, http://cogprints.org/6357 Smith, L.B., & Thelen, E. (2003). Development as a dynamic system. Trends in Cog Sci, Vol.7 (8), pp.343-348. Curr 42 Latest Findings in Intellectual and Developmental Disabilities Research Stearns, S., ed. (1998). Evolution in health and disease. Oxford University Press. Steinlin, M., Schmid, M., et al. (1997). Follow-up in children with Joubert syndrome. Neuropediat, Vol. 28, pp. 204-211. Steinlin, M., Zangger, B., & Boltshauser, E. (1998). Non-progressive congenital ataxia with or without cerebellar hypoplasia: a review of 34 subjects. Dev Med Child Neurol, Vol.40, pp.148-154. Stevens, N.J. (2003). The influence of substrate size, orientation and compliance upon prosimian arboreal quadrupedlism. PhD dissertation, Stony Brook University, Stony Brook, New York. Stevens, N.J. (2008). The effect of branch diameter on primate gait sequence pattern. Am J Primatol, Vol. 70, pp. 356-362. Tammer, R., Hofer, S., et al. (2009). Magnetic resonance imaging of the rhesus monkey brain. Vandenhoeck & Ruprecht, Göttingen, 1 Tan, U. (2005a). Yeni bir sendrom (dört-bilekli yürüyüş, ilkel konuşma, mental retardasyon) ve insan Evrimi. Turkish Academy of Sciences, Ankara. Tan, U. (2005b). Üner Tan sendromu: insan ruhunun evrimine ilişkin yeni bir teori. Turkish Academy of Sciences, Istanbul. Tan, U. (2005c). Unertan sendromu ve insan ruhunun evrimine iliskin yeni bir teori. Biyobank, No. 3 (15). Tan, U. (2005d). Unertan syndrome; quadrupedality, primitive language, and severe mental retardation; a new theory on the evolution of human mind. NeuroQuantology, Vol. 4, pp. 250-255. Tan, U. (2006a). A new syndrome with quadrupedal gait, primitive speech, and severe mental Retardation as a live model for human evolution. Int J Neurosci, Vol. 116, pp. 361-369. Tan U. (2006b). Evidence for “Unertan Syndrome” and the evolution of the human mind. Int J Neurosci, Vol. 16, pp. 763-774. Tan U. (2006c). Evidence for “Unertan Syndrome” as a human model for reverse evolution. Int J Neurosci, Vol. 116, pp. 1539-1547. Tan, U. (2007a). A wrist-walker exhibiting no “Unertan syndrome”: a theory for possible mechanisms of human devolution toward the atavistic walking patterns. Int J Neurosci, Vol. 117, pp. 147-156. Tan, U. (2007b). The psychomotor theory of human mind. Int J Neurosci, Vol. 117, pp. 1109- 1148. Tan, U. (2008). Unertan syndrome: review and report of four new cases. Int J Neurosci, Vol. 118, pp. 211-225. Tan, U. (2010a). Uner Tan syndrome : history, clinical evaluations, genetics, and the dynamics of human quadrupedalism. The Open Neurology Journal, Vol. 4, pp. 78-89. Tan, U. (2010b). Two new cases of Uner Tan syndrome: one man with transition from quadrupedalism to bipedalism; one man with consistent quadrupedalism. Webmedcentral NEUROLOGY, Vol. 1(9) : WMC00645. Tan, U. (2010c). A post-polio paraplegic couple: a woman with palmigrade, saltatoric locomotion; a man with inability to walk: a dynamical systems theoretical prespective. WebmedCentral NEUROLOGY, 1(11):WMC001176. Tan, U., Karaca, S., Tan., et al. (2008). Unertan syndrome: a case series demonstrating human Devolution. Int J Neurosci, Vol. 118, pp. 1-25. Edition. st Üner Tan Syndrome: Review and Emergence of 43 Human Quadrupedalism in Self-Organization, Attractors and Evolutionary Perspectives Tan, U., Pence, S., Yilmaz, M., et al. (2008). Uner Tan syndrome in two Turkish families in relation to devolution and emergence of homo erectus: neurological examination, MRI, and PET scans. Int J Neurosci, Vol. 118, pp. 313-336. Tan, U., & Tan M. (2009). Uner Tan syndrome; a new variant of Unertan syndrome: running on all fours in two upright-walking children. Int J Neurosci, Vol. 119, pp. 909-918. Tan, M., Karaca, S., & Tan, U. (2010). A new case of Uner Tan syndrome – with late- childhood quadrupedalism. Mov Dis, Vol. 25, pp. 652-653. Tan, U., & Tan, M. (2010). First cases of Uner Tan syndrome in Anatolia, with progressive motor improvement, adaptive self-organization and emergence of late-childhood quadrupedalism. Webmedcentral NEUROLOGY, Vol. 1(9): WMC00831. Thelen, E., & Smith, L.B. (1994). A dynamic systems approach to the development of cognition and action. MIT press: Cambridge, Massachusetts, London, England. Teotonio, H., & Rose, M.R. (2000). Variation in the reversibility of evolution. Nature, Vol. 408, pp. 463-466. Teotonio, H., & Rose, M.R. (2001). Perspective: reverse evolution. Int J Org Evol, Vol. 55, pp.653-660. Teotonio, H., & Rose, M.R. (2002). Reverse evolution of fitness in Drosophila melanogaster. J Evol Biol, Vol. 15, pp. 608-617. Tetzlaff, C., Okujeni, S., et al. (2010). Self-organized criticality in developing neural networks. PLoS comp boil, Vol.6 (12), e1001013. Thelen, E. (1994). Motor development : A new synthesis. Am Psychologist, Vol.50, pp.79-95. Thelen, E., & Smith, L.B. (1996). A dynamic systems approach to the development of cognition and action. MIT Press/Bradford book series in cognitive psychology, p. 10. Thelen, E., & Ulrich, B.D. (1991). Hidden skills: a dynamic systems analysis of treadmill stepping during the first year. Monogr Soc Res Child Dev, Vol.56, pp.1-98. Tomic, N., & Meyer-Rochow, V.B. (2011). Atavism medical, genetic, and evolutionary implications. Pers Biol Med, Vol. 54 (3), pp. 332-353. Tschacher, W., Dauwalder, J.-P, & Haken, H. (2003). Self-organizing systems show apparent intentionality. Dynamical systems approach to cognition: Concepts and empirical paradigms based on self-organization. Tschacher, W. (Ed.), World Scientific Publishing Company Inc. Singapore, p.183. Turkmen, S., Demirhan, O., Hoffmann, K., et al. (2006). Cerebellar hypoplasia and quadrupedal locomotion in humans as a recessive trait mapping to chromosome 17p. Med Genet, Vol. 43, pp. 461-464. Turkmen, S., Guo, G., et al. (2009). CA8 mutations cause a novel syndrome characterized by ataxia and mild mental retardation with predisposition to quadrupedal gait. PLoS Genet. May, 5(5) :e1000487. Tvrdik, P., Capecchi, M.R. (2006). Reversal of Hox 1 gene subfunctionilazation in the mouse. Dev Cell, Vol. 11, pp. 239-250. Valente, E.M., Salpietro, D.C., et al. (2003). Description, nomenculature, and mapping of a novel cerebello-renal syndrome with the molar tooth malformation. Am J Hum Genet, Vol. 73, pp. 663-670. Vernier, P., Moreti F., et al. (2004). The degeneration of dopamine neurons in Parkinson’s disease : insights from embryology and evolution of the mesostraitocortical system. Ann NY Acad Sci, Vol. 1035, pp. 231-249. Waldrop, M. (1990). Spontaneous order, evolution, and life. Science, Vol. 247, pp. 1543-1545. 44 Latest Findings in Intellectual and Developmental Disabilities Research Wallace, I.J., & Demes, B. (2008). Symmetrical gaits of Cebus apella: implications for the functional significance of diagonal sequence gait in primates. J Hum Evol, Vol. 54, pp. 783-794. Whiting, M.F., Bradler, S., & Maxwell, T. (2003). Loss and recovery of wings in stick insects. Nature, Vol. 421(16920), pp. 264-267. Wiens, J.J. (2011). Re-evolution of lost mandibular teeth in frogs after more than 200 million years, and re-evaluating Dollo’s law. Evol, Vol. 65(5), pp. 1283-1296. Williams, G.W., & Nesse, R.M. (1991). The dawn of Darwinian medicine. Q Rev Biol, Vol. 66, pp. 1-22. Wilson, D.M. (1961). The central nervous control of flight in a locust. J Exp Biol, Vol.38, pp.471-490. Wood, B. (2002). Hominid revelations from Chad. Nature, Vol. 418, pp. 133-135. Wright, S. (1978). Evolution and the genetics of populations: genetic and biometric foundations. Chicago: Iniversity of Chicago Press. Young, J.W., Patel, B.A., & Stevens, N.J. (2007). Body mass distribution and gait mechanics in fat-tailed dwarf lemurs (Cheirogaleus medius) and patas monkeys (erythrocebus patas). J Hum Evol, Vol. 53, pp. 26-40. Zampieri, F. (2009). Origins and history of Darwinian medicine. Humana.Mente, Vol. 9, pp. 13-38. citation: Tan, Prof. Dr. Uner and Tamam, Prof. Dr. Yusuf and Karaca, Dr. Sibel and Tan, Prof. Dr. Meliha (2012) Üner Tan Syndrome: Review and Emergence of Human Quadrupedalism in Self-Organization, Attractors and Evolutionary Perspectives. [Book Chapter] document_url: http://cogprints.org/8967/1/BOOK%20Chapter%20LATEST%20FINDINGS%20TAN%202012%20Copy.pdf