--- abstract: 'Objective: To evaluate the efficacy of imatinib in chronic myeloid leukemia patients with variant translocations. Methods: Forty eight chronic myeloid leukemia patients carrying variant translocations and treated with imatinib at our institute were considered for the study. Survival and response rates were evaluated. Results: The median follow up was 48 months(m). Forty three (89.58%) patients achieved complete hematologic response. Thirty one (64.58%) patients achieved complete cytogenetic response and 19(39.58%) achieved major molecular response anytime during their follow up period. Only 18.75% of the patients achieved complete cytogenetic response and major molecular response within the stipulated time frames.The estimated overall survival at 48 m median follow up was 81.2%.The progression free survival was also 81.2% and the event free survival was 79.1%.There was no significant survival difference between low vs intermediate and high risk sokal group. Conclusion: We report suboptimal responses to imatinib in chronic myeloid leukemia with variant translocations. Further studies with imatinib and the newer more active drugs dasatinib and nilotinib are justified.' altloc: - http://www.ojhas.org/issue44/2012-4-5.html chapter: ~ commentary: ~ commref: ~ confdates: ~ conference: ~ confloc: ~ contact_email: ~ creators_id: - rohanbhise30@gmail.com - ~ - ~ - ~ - ~ - ~ - ~ - ~ creators_name: - family: Bhise given: R honourific: '' lineage: '' - family: Purohit given: S honourific: '' lineage: '' - family: Lokanatha given: D honourific: '' lineage: '' - family: Jacob given: L honourific: '' lineage: '' - family: Suresh given: TM honourific: '' lineage: '' - family: Govind Babu given: K honourific: '' lineage: '' - family: Babu given: S honourific: '' lineage: '' - family: Lakshmaiah given: KC honourific: '' lineage: '' date: 2013-01-25 date_type: published datestamp: 2013-05-04 23:09:12 department: ~ dir: disk0/00/00/89/34 edit_lock_since: ~ edit_lock_until: 0 edit_lock_user: ~ editors_id: - Kakkilaya BS editors_name: - family: Kakkilaya given: Srinivas honourific: Dr lineage: '' eprint_status: archive eprintid: 8934 fileinfo: /style/images/fileicons/application_pdf.png;/8934/1/2012-4-5.pdf full_text_status: public importid: ~ institution: ~ isbn: ~ ispublished: pub issn: ~ item_issues_comment: [] item_issues_count: ~ item_issues_description: [] item_issues_id: [] item_issues_reported_by: [] item_issues_resolved_by: [] item_issues_status: [] item_issues_timestamp: [] item_issues_type: [] keywords: Chronic myeloid leukemia; Imatinib; Variant translocation lastmod: 2013-05-04 23:09:12 latitude: ~ longitude: ~ metadata_visibility: show note: ~ number: 4(5) pagerange: ~ pubdom: TRUE publication: Online Journal of Health and Allied Sciences publisher: Kakkilaya BS refereed: TRUE referencetext: "1.\tJabbour E, Kantarjian H. 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Blood 2011;117:6793-6800." relation_type: [] relation_uri: [] reportno: ~ rev_number: 11 series: ~ source: ~ status_changed: 2013-05-04 23:09:12 subjects: - OJHAS succeeds: ~ suggestions: ~ sword_depositor: ~ sword_slug: ~ thesistype: ~ title: 'Chronic Myeloid Leukemia with Variant Chromosomal Translocations: Results of Treatment with Imatinib Mesylate.' type: journale userid: 4338 volume: 11