--- abstract: 'Background and objectives: Salivary gland lesions account for 2-6.5% of all the neoplasms of the head and neck. Fine needle aspiration cytology (FNAC) is being increasingly used in the diagnosis of salivary gland lesions. The objective of this study was to evaluate the diagnostic accuracy and the sensitivity and specificity of FNAC in various salivary gland lesions in correlation with their histopathology, which helps in the appropriate therapeutic management. Methods: A total of 120 FNACs were done on salivary gland tumours from July 2010 to June 2012 in the Department of Pathology, P.D.U. Government Medical College, Rajkot (Gujarat, India). Formalin fixed (10%), surgically resected specimens were received, they were processed and slides were prepared for histopathological diagnosis. The stained cytological and histopathological slides were studied, analyzed and correlated. Results: The cytomorphological features were studied and analyzed and the following lesions were observed: Pleomorphic adenoma (88), Warthin’s tumour (2), Cystic lesion (4), Mucoepidermoid carcinoma (6), Acinic cell carcinoma (2), Primary lymphoma (2), Carcinoma EX pleomorphic adenoma(4), metastatic malignancy deposits (2), benign parotid tumour (8) and malignant tumour (unspecified)(2). A histopathological correlation was available in 78 cases. Out of these, 71 cases were true positive, 1 was false positive, 2 were false negative and 4 were true negative. Interpretation and conclusion: The overall sensitivity, specificity and the diagnostic accuracy were 97%, 80% and 92% respectively. Hence, the appropriate therapeutic management could be planned earlier. This study documents that FNAC of the salivary gland tumours is accurate, simple, rapid, inexpensive, well tolerated and harmless for the patient.' altloc: - http://www.ojhas.org/issue43/2012-3-5.htm chapter: ~ commentary: ~ commref: ~ confdates: ~ conference: ~ confloc: ~ contact_email: ~ creators_id: - dr.amit.patho@gmail.com - ~ - ~ - ~ creators_name: - family: Agravat given: AH honourific: '' lineage: '' - family: Dhruva given: GA honourific: '' lineage: '' - family: Pujara given: KM honourific: '' lineage: '' - family: Sanghvi given: HK honourific: '' lineage: '' date: 2012-10-25 date_type: published datestamp: 2013-05-04 23:07:40 department: ~ dir: disk0/00/00/89/15 edit_lock_since: ~ edit_lock_until: 0 edit_lock_user: ~ editors_id: - Kakkilaya BS editors_name: - family: Kakkilaya given: Srinivas honourific: Dr lineage: '' eprint_status: archive eprintid: 8915 fileinfo: /style/images/fileicons/application_pdf.png;/8915/1/2012-3-5.pdf full_text_status: public importid: ~ institution: ~ isbn: ~ ispublished: pub issn: ~ item_issues_comment: [] item_issues_count: ~ item_issues_description: [] item_issues_id: [] item_issues_reported_by: [] item_issues_resolved_by: [] item_issues_status: [] item_issues_timestamp: [] item_issues_type: [] keywords: Salivary gland tumours; FNAC; Diagnostic accuracy; Sensitivity; Specificity; Benign; Malignant lastmod: 2013-05-04 23:07:40 latitude: ~ longitude: ~ metadata_visibility: show note: ~ number: 3(5) pagerange: ~ pubdom: TRUE publication: Online Journal of Health and Allied Sciences publisher: Kakkilaya BS refereed: TRUE referencetext: "1.\tFernandes GC, Pandit AA. Diagnosis of salivary gland tumours by FNAC. Bombay Hospital Journal 2000;42:108-111.\r\n2.\tCrystallini EG, Stafano A, Raffaelle F, Liberati F, Maccio T, Peciarolo A, et al. Fine needle aspiration biopsy of the salivary gland, 1985-1995. Acta Cytol 1997;41:1412-1420.\r\n3.\tEveson JW, Cawson RA. Salivary gland tumours. A review of 2410 cases with particular reference to the histological types, sites, age and sex distribution. J Pathol 1985;146:51-58.\r\n4.\tKline TS, Merriam JM, Shapshay SM. Aspiration biopsy cytology of the salivary gland. Am J Clin Pathol 1981;76:263-269.\r\n5.\tLindberg LG, Akerman M. Aspiration cytology of salivary gland tumours: Diagnostic experience from six years of routine laboratory work. Laryngoscope 1976;86:584-594.\r\n6.\tMavec P, Eneroth CM, Franzen S, Moberger G, Zajicek J. Aspiration biopsy of salivary gland tumours. Acta Otolaryngol 1964;58:471-484.\r\n7.\tPersson PS, Zettergren L. Cytological diagnosis of salivary gland tumours by aspiration biopsy. Acta Cytol 1973;17:351-354.\r\n8.\tCohen MB, Fisher PE, Holly EA, Ljung BM, Lowhagen T, Bottles K. Fine needle aspiration biopsy diagnosis of mucoepidermoid carcinoma. Statistical analysis. Acta Cytol 1990;34:43–49.\r\n9.\tQizilbash AH, Sianos J, Young JE, Archibald SD. Fine needle aspiration biopsy cytology of the major salivary glands. Acta Cytol 1985;29:503-512.\r\n10.\tSpiro RH. Salivary neoplasms- An overview of 35 years of experience with 2807 patients. Head Neck Surg 1986;8:177-184.\r\n11.\tStewart CJ, MacKenzie K, McGarry GW, Mowat A. Fine-needle aspiration cytology of the salivary gland: a review of 341 cases. Diagn Cytopathol 2000; 22:139-146.\r\n12.\tZbaren P, Nuyens M, Loosli H, Stauffer E. Diagnostic accuracy of fine-needle aspiration cytology and frozen sections in primary parotid carcinoma. Cancer 2004;100:1876-1883 .\r\n13.\tLayfield LJ, Tan P, Glasgow BJ. Fine-needle aspiration of salivary gland lesions. Comparison with frozen sections and histological findings. Arch Pathol Lab Med 1987;111:346-353.\r\n14.\tHood IC, Qizilbash AH, Salama SS, Alexopoulou I. Basal-cell adenoma of the parotid. Difficulty in the differentiation from adenoid cystic carcinoma on aspiration biopsy. Acta Cytol 1983;27:515-520.\r\n15.\tMatsushita I, Takeda T, Tadao Kobayashi TK, Tanaka B, Sawaraqi I. Mucoepidermoid carcinoma of the salivary gland in pleural fluid. A case report. Acta Cytol 1983;27:525-528.\r\n16.\tAgale SV, D’Costa GF, Hastak MS, Shedge RT. Primary non-Hodgkin’s lymphoma of the salivary gland: A spectrum of lymphoepithelial sialadenitis and low-grade B-cell lymphoma of the mucosa-associated lymphoid tissue with transformation to high-grade lymphoma. Indian J Pathol Microbiol 2010;53:364-367." relation_type: [] relation_uri: [] reportno: ~ rev_number: 9 series: ~ source: ~ status_changed: 2013-05-04 23:07:40 subjects: - OJHAS succeeds: ~ suggestions: ~ sword_depositor: ~ sword_slug: ~ thesistype: ~ title: 'Role of Fine Needle Aspiration Cytology in Salivary Gland Pathology and its Histopathological Correlation: A Two Year Prospective Study in Western India.' type: journale userid: 4338 volume: 11