creators_name: GA, Dhruva creators_name: Agravat, AH creators_name: Sanghvi, HK creators_id: dr.sanghvihardik@yahoo.com editors_name: Kakkilaya, Srinivas editors_id: Kakkilaya BS type: journale datestamp: 2013-05-04 23:07:28 lastmod: 2013-05-04 23:07:28 metadata_visibility: show title: Atherosclerosis of Coronary Arteries as Predisposing Factor in Myocardial Infarction: An Autopsy Study. ispublished: pub subjects: OJHAS full_text_status: public keywords: Atherosclerosis; Coronary; Plaque; Autopsy; Infarction. abstract: The incidence of coronary heart disease has markedly increased in India over the past few years. Ischemic heart disease, the largest cause of morbidity and mortality in the developed and developing countries today is overwhelmingly contributed by atherosclerosis. The study highlights the impact of atherosclerotic lesions in the population of Rajkot district. We studied atherosclerotic lesions in coronary arteries in cases subjected to autopsy in last 4 years, to grade and to evaluate the atheromatous plaques; and to assess the cases of myocardial infarction amongst them. The study comprises dissected specimens of heart in total 360 cases subjected for autopsy. The vessels were examined for the presence of atherosclerotic lesions which were graded according to American Heart Association and examined for evidence of myocardial infarction. The study comprises the cases in age group between 20 to 80 years. Commonest type of atherosclerosis seen was grade-4. Left Anterior Descending Coronary was most commonly involved artery. Myocardial infarction was the cause of death in 35 cases (9.72%) The data obtained may form a baseline for the forthcoming studies. date: 2012-10-25 date_type: published publication: Online Journal of Health and Allied Sciences volume: 11 number: 3(1) publisher: BS Kakkilaya refereed: TRUE referencetext: 1. Indrayan A. Forecasting vascular disease cases and associated mortality in India. NCMH Background Papers: Burden of Disease in India. National Commission on Macroeconomics and Health, Government of India. 2005; 2. Widimsky P, Andel M. Prevalence of coronary atherosclerosis in asymptomatic population. Eur Heart J 2000;21:13-14. 3. Bertomeu A, García-Vidal O, Farré X, Galobart A, Vázquez M, Laguna JC, Ros E. Preclinical coronary atherosclerosis in a population with low incidence of myocardial infarction: cross sectional autopsy study. BMJ2003;327:591-592. 4. Stary HC. Natural History and Histological Classification of Atherosclerotic Lesions: An Update. Arterioscler Thromb Vasc Biol 2000;20;1177-1178. 5. Bhargava MK, Bhargava SK. Coronary atherosclerosis in North Karnataka. Indian J Pathol Microbiol 1975;18:65-77. 6. Murthy MSN, Dutta BN, Ramalingaswami V. Coronary atherosclerosis in North India (Delhi Area). J Pathol Bacteriol 1963;85:93-101. 7. Singh H, Oberoi SS, Gorea RK, Bal MS. Atherosclerosis in Coronaries in Malwa Region of Punjab. J Indian Acad Forensic Med 2005;27(4):32-35. 8. Padmavati S, Sandhu I. Incidence of coronary artery disease in Delhi from medico-legal autopsies. Indian Journal of Medical Research 1969; 57:465-475. 9. Tandon OP, Aggarwal VC, Katiyar BC. Coronary and aortic atherosclerosis. Indian Heart J 1969;5:10 10. Garg M, Agarwal AD, Kataria SP. Coronary Atherosclerosis and Myocardial infarction: An Autopsy Study. J Indian Acad Forensic Med. Jan-Mar 2011;33(1):39-42. Available at http://medind.nic.in/jal/t11/i1/jalt11i1p39.pdf 11. Sudha ML, Sundaram S, Purushothaman KR, Kumar PS, Prathiba D. Coronary atherosclerosis in sudden cardiac death: An autopsy study. Indian J Pathol Microbiol 2009;52(4):486-489. 12. Virmani R, Kolodgie FD, Burke AP, Farb A, Schwartz SM. Lessons from sudden coronary death – A comprehensive morphological classification scheme for atherosclerotic lesions. Arterioscler Thromb Vasc Biol2000;20:1262-1275. 13. Stary HC, Chandler AB, Glagov S, Guyton JR, Insull W, Rosenfeld ME, Schaffer A, Schwartz CJ, Wagner WD, Wissler RW. A definition of initial, fatty streak, and intermediate lesions of atherosclerosis. Arterioscler Thromb.1994;14:840–856. 14. Farb A, Tang AL, Burke AP, Sessums L, Liang Y, Virmani R. Sudden coronary death – Frequency of active coronary lesions, inactive coronary lesions and myocardial infarction. Circulation 1995;92:1701-1709. 15. Golshahi J, Rojabi P, Golshahi F. Frequency of atherosclerotic lesions in coronary arteries of autopsy specimens in Isfahan forensic medicine center. J Res Med 2005;1(10):16-19. 16. Yazdi SAT, Rezaei A, Azari JB, Hejazi A, Shakeri MT, Shahri MK. Prevalence of Atherosclerotic Plaques in Autopsy Cases with Noncardiac Death. Iranian J Pathol 2009;4(3):101-104. 17. Wig KL, Malhotra RP, Chitkara NL, Gupta SP. Prevalence of Coronary Atherosclerosis In Northern India. BMJ 1962;2:510-513. 18. Maru M. Coronary atherosclerosis and myocardial infarction in autopsied patients in Gondar, Ethiopia. J R Soc Med 1989;82(7):399-401. citation: GA, Dhruva and Agravat, AH and Sanghvi, HK (2012) Atherosclerosis of Coronary Arteries as Predisposing Factor in Myocardial Infarction: An Autopsy Study. [Journal (On-line/Unpaginated)] document_url: http://cogprints.org/8911/1/2012-3-1.pdf