creators_name: Sufi, AR creators_name: Singh, T creators_id: aaliarasool_s@yahoo.com editors_name: Kakkilaya, Srinivas editors_id: Kakkilaya BS type: journale datestamp: 2013-05-04 23:03:58 lastmod: 2013-05-04 23:03:58 metadata_visibility: show title: Granulocytic Sarcoma as the First Sign of Acute Leukemia in Childhood ispublished: pub subjects: OJHAS full_text_status: public keywords: Granulocytic sarcoma; Acute myeloid leukemia; Proptosis. abstract: Acute myeloid leukemia (AML) may rarely involve the orbit as a solid tumor termed granulocytic sarcoma. This report describes the case of a child who presented with rapidly progressive unilateral proptosis and was diagnosed as rhabdomyosarcoma. However subsequent examination of the peripheral blood film revealed AML. Thus proptosis may present as the initial manifestation of AML. date: 2012-01-15 date_type: published publication: Online Journal of Health and Allied Sciences volume: 10 number: 4(9) publisher: BS Kakkilaya refereed: TRUE referencetext: 1. Sethi A, Ghose S, Gujral S, Jain P, Kumar R. Childhood proptosis: The invaluable, though often overlooked peripheral blood smear. Indian J Ophthalmol 2001;49(2):121-123. 2. Alkatan H, Chaudhry I. Myeloid sarcoma of the orbit. Annals of Saudi Medicine 2008;28(6):461-465. 3. Shields JA, Stopyra GA, Marr BP, Shields CL. Bilateral Orbital Myeloid Sarcoma as Initial Sign of Acute Myeloid Leukemia: Case Report and Review of the Literature. Arch Ophthalmol 2003;121:138-142. 4. Bekassy AN, Hermans J, Gorrin NC, Gratwohl A . Granulocytic sarcoma after allogenic BMT: a retrospective European multicenter survey. Bone Marrow Transplant 1996;17:801-808. 5. Davis JL, Parke DW 2nd, Font RL. Granulocytic sarcoma of the orbit. A clinicopathologic study. Ophthamol 1985;92(12):1758-1762. 6. Byrd JC, Edenfield J, Shields DJ, et al. Extramedullary myeloid cell tumors in acute non-lymphocytic leukemia: a clinical review. J Clin Oncol 1995; 13: 1800-1816. 7. Zimmerman LE, Font RL. Ophthalmologic manifestations of granulocytic sarcoma (myeloid sarcoma or chloroma): the third Pan American Association of Ophthalmology and American Journal of Ophthalmology Lecture. Am J Ophthalmol 1975;80:975-990. 8. Ghose S, Kumar R,Chaudhuri S, Jain Y,Gujral S, Singh H, et al. Importance of bone marrow examination in childhood proptosis In: Pasricha JK. (ed). Indian Ophthalmology Year Book 1997, Proc 55th All India Ophthalmol Soc Conf. New Delhi. 1997. pp 414-416. 9. da Fonseca Junior NL, Paves L, Nakanami DM, Seivas MT, Manso PG. Sarcoma granulocitico em orbita: relato de caso. Arq Bras Ofthalmol 2005;68(4):557-560. citation: Sufi, AR and Singh, T (2012) Granulocytic Sarcoma as the First Sign of Acute Leukemia in Childhood. [Journal (On-line/Unpaginated)] document_url: http://cogprints.org/8859/1/2011-4-9.pdf