--- abstract: "Objective: To determine the effects of plant extract, nicotine and caffeine on the activities of the liver metabolizing-enzyme induced by pentobarbitone. Materials and Method: Seven groups of mice were pretreated with high doses of sample extracts (0.4 mg/g body weight sample extract, but nicotine at 0.1 mg/g body weight) and one control group was pretreated with saline. On day 5, pentobarbitone (0.005 ml of 8 mg/ml) was administered and the sleeping time was determined. The test was repeated but at low doses (0.1 mg/g body weight sample extract, but nicotine at 0.05mg/g body weight). Results: At high doses, bitter gourd, 'tempeh', nicotine, caffeine, nicotine+bitter gourd, nicotine+'tempeh' and nicotine+caffeine induced the activities of liver metabolizing enzyme significantly compared to control. At low doses, bitter gourd, nicotine, caffeine, nicotine+bitter gourd, nicotine+'tempeh' and nicotine+caffeine induced the enzyme but 'tempeh' did not. Conclusion: The findings suggest that bitter gourd, nicotine and caffeine act as enzyme inducers, but 'tempeh' only demonstrate this ability at high dose." altloc: [] chapter: ~ commentary: ~ commref: ~ confdates: ~ conference: ~ confloc: ~ contact_email: ~ creators_id: [] creators_name: - family: Robson given: Noorzurani honourific: '' lineage: '' - family: Mustafa given: A. M. honourific: '' lineage: '' date: 2008 date_type: published datestamp: 2012-11-09 19:02:25 department: ~ dir: disk0/00/00/82/55 edit_lock_since: ~ edit_lock_until: 0 edit_lock_user: ~ editors_id: [] editors_name: [] eprint_status: archive eprintid: 8255 fileinfo: /style/images/fileicons/text_html.png;/8255/1/the-effect-of-pretreatment-with-plant-extract-nicotine-and-caffeine-on-sleeping-time-induced-by-pentobarbitone-in-mice.html|/style/images/fileicons/text_html.png;/8255/2/the-effect-of-pretreatment-with-plant-extract-nicotine-and-caffeine-on-sleeping-time-induced-by-pentobarbitone-in-mice.html full_text_status: public importid: ~ institution: ~ isbn: ~ ispublished: pub issn: ~ item_issues_comment: [] item_issues_count: ~ item_issues_description: [] item_issues_id: [] item_issues_reported_by: [] item_issues_resolved_by: [] item_issues_status: [] item_issues_timestamp: [] item_issues_type: [] keywords: 'caffeine, cytochrome, enzyme, extracts, inducer, liver, metabolizing-enzyme, nicotine, p450, plant, ' lastmod: 2012-11-09 19:02:25 latitude: ~ longitude: ~ metadata_visibility: show note: ~ number: 2 pagerange: ~ pubdom: TRUE publication: Internet Journal of Pharmacology publisher: ~ refereed: TRUE referencetext: ~ relation_type: [] relation_uri: [] reportno: ~ rev_number: 11 series: ~ source: ~ status_changed: 2012-05-13 12:50:06 subjects: - soc-psy succeeds: ~ suggestions: ~ sword_depositor: ~ sword_slug: ~ thesistype: ~ title: 'The effect of pretreatment with plant extract, nicotine and caffeine on sleeping time induced by pentobarbitone in mice' type: journale userid: 16139 volume: 5