creators_name: Robson, Noorzurani
creators_name: Mustafa, A. M.
type: journale
datestamp: 2012-11-09 19:02:25
lastmod: 2012-11-09 19:02:25
metadata_visibility: show
title: The effect of pretreatment with plant extract, nicotine and caffeine on sleeping time induced by pentobarbitone in mice
ispublished: pub
subjects: soc-psy
full_text_status: public
keywords: caffeine, cytochrome, enzyme, extracts, inducer, liver, metabolizing-enzyme, nicotine, p450, plant, 
abstract: Objective: To determine the effects of plant extract, nicotine and caffeine on the activities of the liver metabolizing-enzyme induced by pentobarbitone. Materials and Method: Seven groups of mice were pretreated with high doses of sample extracts (0.4 mg/g body weight sample extract, but nicotine at 0.1 mg/g body weight) and one control group was pretreated with saline. On day 5, pentobarbitone (0.005 ml of 8 mg/ml) was administered and the sleeping time was determined. The test was repeated but at low doses (0.1 mg/g body weight sample extract, but nicotine at 0.05mg/g body weight). Results: At high doses, bitter gourd, 'tempeh', nicotine, caffeine, nicotine+bitter gourd, nicotine+'tempeh' and nicotine+caffeine induced the activities of liver metabolizing enzyme significantly compared to control. At low doses, bitter gourd, nicotine, caffeine, nicotine+bitter gourd, nicotine+'tempeh' and nicotine+caffeine induced the enzyme but 'tempeh' did not. Conclusion: The findings suggest that bitter gourd, nicotine and caffeine act as enzyme inducers, but 'tempeh' only demonstrate this ability at high dose.
date: 2008
date_type: published
publication: Internet Journal of Pharmacology
volume: 5
number: 2
refereed: TRUE
citation:   Robson, Noorzurani and Mustafa, A. M.  (2008) The effect of pretreatment with plant extract, nicotine and caffeine on sleeping time induced by pentobarbitone in mice.  [Journal (On-line/Unpaginated)]     
document_url: http://cogprints.org/8255/1/the-effect-of-pretreatment-with-plant-extract-nicotine-and-caffeine-on-sleeping-time-induced-by-pentobarbitone-in-mice.html
document_url: http://cogprints.org/8255/2/the-effect-of-pretreatment-with-plant-extract-nicotine-and-caffeine-on-sleeping-time-induced-by-pentobarbitone-in-mice.html