?url_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Adc&rft.title=Erythromycin+induced+Torsade+de+Pointes+in+a+Methadone+maintenance+patient%3ACase+Report&rft.creator=Robson+%2C+Noorzurani+&rft.creator=Habil%2C+Mohamad+Hussain+&rft.subject=Social+Psychology&rft.description=Objective%3A+This+case+report+highlights+the+risk+of+Torsade+de+Pointes+(TdP)%2C+a+life+threatening+cardiac+arrhythmia+in+a+heroin+dependent+patient+receiving+methadone+substitution+therapy+who+was+prescribed+erythromycin+for+upper+respiratory+tract+infection.+Method%3A+We+report+a+case+of+a+35-year-old+Malay+man+on+methadone+maintenance+treatment+who+developed+TdP+possibly+due+to+drug+interaction+between+methadone+and+erythromycin.+Results%3A+The+patient+reported+feeling+unwell%2C+chest+pain+and+feeling+dizzy+after+consuming+2+doses+of+erythromycin.+ECG+monitoring+showed+prolonged+rate-corrected+QT+interval+leading+to+TdP.+The+patient+was+admitted+to+the+ward+where+the+cardiac+arrhythmia+ceased+following+methadone+discontinuation.+This+cardiac+arrhythmia+was+most+likely+due+to+drug+interaction+between+methadone+and+erythromycin+(an+enzyme+inhibitor)+which+led+to+an+increase+in+methadone+concentration+and+potentiated+the+adverse+effects.+Conclusion%3A+As+methadone+is+a+beneficial+treatment+for+heroin+dependent+patients%2C+the+risk+of+cardiac+arrhythmia+is+of+great+concern.+To+avoid+complications+of+drug+interaction%2C+patients+on+methadone+therapy+should+be+advised+to+seek+medical+assessment+before+taking+other+drugs.+As+TdP+is+life+threatening%2C+it+is+thus+important+that+physicians+and+psychiatrists+involved+in+the+treatment+of+heroin+dependent+patients+on+methadone+substitution+therapy+be+made+aware+of+this+risk.&rft.date=2010&rft.type=Journal+(Paginated)&rft.type=PeerReviewed&rft.format=application%2Fpdf&rft.identifier=http%3A%2F%2Fcogprints.org%2F8250%2F1%2FASEAN_3_6_Noorzurani.pdf&rft.identifier=++Robson+%2C+Noorzurani++and+Habil%2C+Mohamad+Hussain+++(2010)+Erythromycin+induced+Torsade+de+Pointes+in+a+Methadone+maintenance+patient%3ACase+Report.++%5BJournal+(Paginated)%5D+++++&rft.relation=http%3A%2F%2Fcogprints.org%2F8250%2F