creators_name: Pomrenze, M creators_name: Baratta, M creators_name: Cadle, B creators_name: Cooper, D.C. type: journalp datestamp: 2012-11-09 19:37:13 lastmod: 2012-11-09 19:37:13 metadata_visibility: show title: Cocaine self-administration in the mouse: A low- cost, chronic catheter preparation ispublished: unpub subjects: behav-neuro-sci subjects: neuro-pharm full_text_status: public keywords: mouse self-administration, intravenous catheter, addiction abstract: Intravenous drug self-administration is the most valid animal model of human addiction because it allows volitional titration of the drug in the blood based on an individual’s motivational state together with the pharmacokinetic properties of the drug. Here we describe a reliable low-cost mouse self-administration catheter assembly and protocol that that can be used to assess a variety of drugs of abuse with a variety of protocols. We describe a method for intravenous catheter fabrication that allows for efficient and long-lasting intravenous drug delivery. The intravenous catheters remained intact and patent for several weeks allowing us to establish stable maintenance of cocaine acquisition. This was followed by a dose response study in the same mice. For collaborators interested in premade catheters for research please make a request at www.neuro-cloud.net/nature-precedings/pomerenze. date: 2012-03-29 date_type: published publication: Nature Precedings volume: March publisher: Nature Publishing Group refereed: FALSE referencetext: 1. Kelley, B.M. et al. (1997). Phys and Behv, 62(1): 163 167. 2. Thomsen, M. et al. (2006). Psychopharm, 184: 145 154. 3. Chen, B.T et al. (2008). Neuron, 59: 288-297 . 4. Caine, S.B. et al. (1999). Psychopharm, 147: 22-24. Page 2 of 2 citation: Pomrenze, M and Baratta, M and Cadle, B and Cooper, D.C. (2012) Cocaine self-administration in the mouse: A low- cost, chronic catheter preparation. [Journal (Paginated)] (Unpublished) document_url: http://cogprints.org/8143/1/pom-13.pdf document_url: http://cogprints.org/8143/7/bibliography.txt