--- abstract: "Neuromodulators, like dopamine, have considerable influence on the\r\nprocessing capabilities of neural networks. \r\nThis has for instance been shown in the working memory functions\r\nof prefrontal cortex, which may be regulated by altering the\r\ndopamine level. Experimental work provides evidence on the biochemical\r\nand electrophysiological actions of dopamine receptors, but there are few \r\ntheories concerning their significance for computational properties \r\n(ServanPrintzCohen90,Hasselmo94).\r\nWe point to experimental data on neuromodulatory regulation of \r\ntemporal properties of excitatory neurons and depolarization of inhibitory \r\nneurons, and suggest computational models employing these effects.\r\nChanges in membrane potential may be modelled by the firing threshold,\r\nand temporal properties by a parameterization of neuronal responsiveness \r\naccording to the preceding spike interval.\r\nWe apply these concepts to two examples using spiking neural networks.\r\nIn the first case, there is a change in the input synchronization of\r\nneuronal groups, which leads to\r\nchanges in the formation of synchronized neuronal ensembles.\r\nIn the second case, the threshold\r\nof interneurons influences lateral inhibition, and the switch from a \r\nwinner-take-all network to a parallel feedforward mode of processing.\r\nBoth concepts are interesting for the modeling of cognitive functions and may\r\nhave explanatory power for behavioral changes associated with dopamine \r\nregulation." altloc: [] chapter: ~ commentary: ~ commref: ~ confdates: ~ conference: ~ confloc: ~ contact_email: ~ creators_id: - gscheler@gmail.com creators_name: - family: Scheler given: Gabriele honourific: '' lineage: '' date: 2001-08-10 date_type: completed datestamp: 2012-11-09 19:34:57 department: ~ dir: disk0/00/00/80/82 edit_lock_since: ~ edit_lock_until: 0 edit_lock_user: ~ editors_id: [] editors_name: [] eprint_status: archive eprintid: 8082 fileinfo: application/pdf;http://cogprints.org/8082/1/neural%2Dnetworks%2D2012.pdf full_text_status: public importid: ~ institution: ~ isbn: ~ ispublished: inpress issn: ~ item_issues_comment: [] item_issues_count: ~ item_issues_description: [] item_issues_id: [] item_issues_reported_by: [] item_issues_resolved_by: [] item_issues_status: [] item_issues_timestamp: [] item_issues_type: [] keywords: "synchronization, spiking neural networks, \r\nneuromodulation, dopamine, cortical networks, spike frequency adaptation,\r\nensemble formation" lastmod: 2012-11-09 19:34:57 latitude: ~ longitude: ~ metadata_visibility: show note: 'Paper was not published in 2001; certain theoretical aspects of dopamine modulation outlined in the paper, esp. on ensemble formation, remain unexplored and potentially significant.' number: ~ pagerange: ~ pubdom: TRUE publication: accepted at Neural Networks in 2001 publisher: ~ refereed: TRUE referencetext: "\r\nJ.H. 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