--- abstract: 'Anticardiolipin antibody (aCL) is considered to be an independent risk factor while high sensitivity C reactive protein (hsCRP) is an established marker for coronary artery disease. This study was conducted to determine levels of aCL antibodies and hsCRP, their correlation and role in predicting recurrence of events in patients presenting with Acute Coronary Syndrome (ACS). Sixty patients admitted with Acute Coronary Syndrome were followed up for 7 days or until discharge. Patients were classified into two groups as those having experienced an ischemic event needing intervention within 7 days (Group I) and other having an event free recovery (Group II). aCL antibody and hsCRP levels were estimated and compared in these two groups. Twenty age and sex matched disease free persons served as controls. The levels of aCL were significantly higher in patients with ACS as compared to the controls (p=0.020). However the levels of aCL in Group I (13.39±9.46 GPL-U/ml) and Group II (13.51±9.93 GPL-U/ml) were not significantly different (p =0.838). The mean hsCRP levels were higher in cases with an event (23.30±10.68 mg/dl) than in cases without an event (20.60±11.45mg/dl) though it was not significant statistically (p=0.389). aCL and CRP were not found to be significantly correlated in causing the recurrence of events(p=0.178). Therefore anticardiolipin antibody is an independent risk factor which could be implicated in the pathogenesis of ACS. However it is not significantly associated with recurrence of short-term events in patients with ACS. Also, aCL antibody does not have significant correlation with hSCRP in causing recurrence of events in the patients of acute coronary syndrome.' altloc: - http://www.ojhas.org/issue37/2011-1-12.htm chapter: ~ commentary: ~ commref: ~ confdates: ~ conference: ~ confloc: ~ contact_email: ~ creators_id: - ~ - rajeevsharma.md@gmail.com - ~ - ~ - ~ - ~ - ~ creators_name: - family: Malhotra given: AS honourific: '' lineage: '' - family: Sharma given: R honourific: '' lineage: '' - family: Mehta given: J honourific: '' lineage: '' - family: Kashyap given: JR honourific: '' lineage: '' - family: Gupta given: V honourific: '' lineage: '' - family: Kapoor given: N honourific: '' lineage: '' - family: Sachdev given: A honourific: '' lineage: '' date: 2011-04-15 date_type: published datestamp: 2011-12-15 23:59:53 department: ~ dir: disk0/00/00/78/23 edit_lock_since: ~ edit_lock_until: 0 edit_lock_user: ~ editors_id: - Kakkilaya BS editors_name: - family: Kakkilaya given: Srinivas honourific: Dr lineage: ~ eprint_status: archive eprintid: 7823 fileinfo: application/pdf;http://cogprints.org/7823/1/2011%2D1%2D12.pdf full_text_status: public importid: ~ institution: ~ isbn: ~ ispublished: pub issn: ~ item_issues_comment: [] item_issues_count: ~ item_issues_description: [] item_issues_id: [] item_issues_reported_by: [] item_issues_resolved_by: [] item_issues_status: [] item_issues_timestamp: [] item_issues_type: [] keywords: Acute coronary syndrome; Anticardiolipin antibodies; High sensitivity C -reactive protein; Myocardial infarction; Composite end point lastmod: 2011-12-15 23:59:53 latitude: ~ longitude: ~ metadata_visibility: show note: ~ number: 1 pagerange: ~ pubdom: TRUE publication: Online Journal of Health and Allied Sciences publisher: Dr. BS Kakkilaya refereed: TRUE referencetext: "1.\tFeinbloom D, Bauer KA. 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Clinical application of C-reactive protein for cardiovascular disease detection and prevention [review]. Circulation. 2003;107:363-369." relation_type: [] relation_uri: [] reportno: ~ rev_number: 9 series: ~ source: ~ status_changed: 2011-12-15 23:59:53 subjects: - OJHAS succeeds: ~ suggestions: ~ sword_depositor: ~ sword_slug: ~ thesistype: ~ title: 'Determination and Correlation of Anticardiolipin Antibody with High Sensitivity C- reactive Proteins and its Role in Predicting Short Term Outcome in Patients with Acute Coronary Syndrome' type: journale userid: 4338 volume: 10