?url_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Adc&rft.title=Determination+and+Correlation+of+Anticardiolipin+Antibody+with+High+Sensitivity+C-+reactive+Proteins+and+its+Role+in+Predicting+Short+Term+Outcome+in+Patients+with+Acute+Coronary+Syndrome&rft.creator=Malhotra%2C+AS&rft.creator=Sharma%2C+R&rft.creator=Mehta%2C+J&rft.creator=Kashyap%2C+JR&rft.creator=Gupta%2C+V&rft.creator=Kapoor%2C+N&rft.creator=Sachdev%2C+A&rft.subject=Online+Journal+of+Health+and+Allied+Sciences&rft.description=Anticardiolipin+antibody+(aCL)+is+considered+to+be+an+independent+risk+factor+while+high+sensitivity+C+reactive+protein+(hsCRP)+is+an+established+marker+for+coronary+artery+disease.+This+study+was+conducted+to+determine+levels+of+aCL+antibodies+and+hsCRP%2C+their+correlation+and+role+in+predicting+recurrence+of+events+in+patients+presenting+with+Acute+Coronary+Syndrome+(ACS).+Sixty+patients+admitted+with+Acute+Coronary+Syndrome+were+followed+up+for+7+days+or+until+discharge.+Patients+were+classified+into+two+groups+as+those+having+experienced+an+ischemic+event+needing+intervention+within+7+days+(Group+I)+and+other+having+an+event+free+recovery+(Group+II).+aCL+antibody+and+hsCRP+levels+were+estimated+and+compared+in+these+two+groups.+Twenty+age+and+sex+matched+disease+free+persons+served+as+controls.+The+levels+of+aCL+were+significantly+higher+in+patients+with+ACS+as+compared+to+the+controls+(p%3D0.020).+However+the+levels+of+aCL+in+Group+I+(13.39%C2%B19.46+GPL-U%2Fml)+and+Group+II+(13.51%C2%B19.93+GPL-U%2Fml)+were+not+significantly+different+(p+%3D0.838).+The+mean+hsCRP+levels+were+higher+in+cases+with+an+event+(23.30%C2%B110.68+mg%2Fdl)+than+in+cases+without+an+event+(20.60%C2%B111.45mg%2Fdl)+though+it+was+not+significant+statistically+(p%3D0.389).+aCL+and+CRP+were+not+found+to+be+significantly+correlated+in+causing+the+recurrence+of+events(p%3D0.178).+Therefore+anticardiolipin+antibody+is+an+independent+risk+factor+which+could+be+implicated+in+the+pathogenesis+of+ACS.+However+it+is+not+significantly+associated+with+recurrence+of+short-term+events+in+patients+with+ACS.+Also%2C+aCL+antibody+does+not+have+significant+correlation+with+hSCRP+in+causing+recurrence+of+events+in+the+patients+of+acute+coronary+syndrome.&rft.publisher=Dr.+BS+Kakkilaya&rft.contributor=Kakkilaya%2C+Dr+Srinivas&rft.date=2011-04-15&rft.type=Journal+(On-line%2FUnpaginated)&rft.type=PeerReviewed&rft.format=application%2Fpdf&rft.identifier=http%3A%2F%2Fcogprints.org%2F7823%2F1%2F2011-1-12.pdf&rft.identifier=++Malhotra%2C+AS+and+Sharma%2C+R+and+Mehta%2C+J+and+Kashyap%2C+JR+and+Gupta%2C+V+and+Kapoor%2C+N+and+Sachdev%2C+A++(2011)+Determination+and+Correlation+of+Anticardiolipin+Antibody+with+High+Sensitivity+C-+reactive+Proteins+and+its+Role+in+Predicting+Short+Term+Outcome+in+Patients+with+Acute+Coronary+Syndrome.++%5BJournal+(On-line%2FUnpaginated)%5D+++++&rft.relation=http%3A%2F%2Fcogprints.org%2F7823%2F