--- abstract: 'An overview of translational, human oncogenomics, transcriptomics and cancer interactomic networks is presented together with basic concepts and potential, new applications to Oncology and Integrative Cancer Biology. Novel translational oncogenomics research is rapidly expanding through the application of advanced technology, research findings and computational tools/models to both pharmaceutical and clinical problems. A self-contained presentation is adopted that covers both fundamental concepts and the most recent biomedical, as well as clinical, applications. Sample analyses in recent clinical studies have shown that gene expression data can be employed to distinguish between tumor types as well as to predict outcomes. Potentially important applications of such results are individualized human cancer therapies or, in general, ‘personalized medicine’. Several cancer detection techniques are currently under development both in the direction of improved detection sensitivity and increased time resolution of cellular events, with the limits of single molecule detection and picosecond time resolution already reached. The urgency for the complete mapping of a human cancer interactome with the help of such novel, high-efficiency / low-cost and ultra-sensitive techniques is also pointed out.' altloc: [] chapter: 22 commentary: ~ commref: ~ confdates: ~ conference: ~ confloc: ~ contact_email: ~ creators_id: - ibaianu@illinois.edu creators_name: - family: Baianu given: I.C. honourific: Prof. Dr lineage: '' date: 2010-05-15 date_type: completed datestamp: 2011-12-16 00:59:06 department: ~ dir: disk0/00/00/77/56 edit_lock_since: ~ edit_lock_until: 0 edit_lock_user: ~ editors_id: [] editors_name: [] eprint_status: archive eprintid: 7756 fileinfo: application/pdf;http://cogprints.org/7756/1/TranslOnco66p_npre20116190.pdf|text/html;http://cogprints.org/7756/7/TranslOnco66p_npre20116190.doc full_text_status: public importid: ~ institution: ~ isbn: ~ ispublished: inpress issn: ~ item_issues_comment: [] item_issues_count: ~ item_issues_description: [] item_issues_id: [] item_issues_reported_by: [] item_issues_resolved_by: [] item_issues_status: [] item_issues_timestamp: [] item_issues_type: [] keywords: 'signalling pathways, interactomics, genomic techniques, pharmaceutical and clinical aspects of oncogenomics' lastmod: 2011-12-16 00:59:06 latitude: ~ longitude: ~ metadata_visibility: show note: To be published in ``Bioinformatics" in 2011 number: ~ pagerange: 1-65 pubdom: FALSE publication: Bioinformatics publisher: In-Tech refereed: FALSE referencetext: "Ashburner M, et al. 2000. Gene ontology: tool for the unification of biology. The Gene Ontology Consortium. Nature Genetics, 25: 25-29.\r\n\r\n2.Bagatolli LA, Gratton, E. 2000. Two-photon fluorescence microscopy of coexisting lipid domains in giant unilamellar vesicles of binary phospholipid mixtures. Biophys. J., 78: 290-305.\r\n\r\n3.Bagui, TK, Jackson RJ, Agrawal D, and Pledger WJ. 2000. Analysis of cyclin D3-cdk4 complexes in fibroblasts expressing and lacking p27kip1 and p21cip1. Mol. Cell. Biol., 20: 8748– 57. \r\n\r\n4.Baianu, I. 1971. Organismic Structures and Qualitative Dynamics of Systems. Bull. Math. Biophys., 33: 339-53. \r\n\r\n5.Baianu IC. 1977. A Logical Model of Genetic Activities in Lukasiewicz Algebras: The Non-linear Theory. Bull. Math. Biology, 39: 249-58.\r\n\r\n6. Baianu IC. 1980. Natural Transformations of Organismic Structures, Bull. Math. Biology, 4(2): 431-446.\r\n\r\n7. Baianu I.C. 1983. Natural Transformation Models in Molecular Biology, Proceedings of the SIAM Natl. Meet., Denver, CO.; Eprint URLs:\r\nhttp://cogprints.org/3675/;\r\nhttp://cogprints.org/3675/01/Naturaltransfmolbionu6.pdf~ .\r\n\r\n8. Baianu IC. 1984. A Molecular--Set--Variable Model of Structural and Regulatory Activities in Metabolic and Genetic Networks. FASEB Proceedings, 43: 917.\r\n9. Baianu IC. 1987a. Computer Models and Automata Theory in Biology and Medicine., in M. Witten (ed.), Mathematical Models in Medicine, vol.7., New York : Pergamon Press. p.1513-77; CERN Preprint No. EXT--2004—072,URL:\r\nhttp://doc.cern.ch//archive/electronic/other/ext/ext-2004-072.pdf ~.\r\n\r\n10. Baianu IC. 1987b. Molecular Models of Genetic and Organismic Structures., CERN Preprint Archive. EXT--2004--067, p.1- 12. URL:\r\nhttp://doc.cern.ch/archive/electronic/other/ext/ext-2004-067/MolecularModelsICB3.doc ~.\r\n" relation_type: [] relation_uri: [] reportno: ~ rev_number: 18 series: ~ source: ~ status_changed: 2011-12-16 00:59:06 subjects: - bio-theory - clin-psy - comp-sci-complex-theory - comp-sci-hci - comp-sci-mach-dynam-sys - neurgen succeeds: ~ suggestions: ~ sword_depositor: ~ sword_slug: ~ thesistype: ~ title: Oncogenomics and Cancer Interactomics type: bookchapter userid: 4959 volume: ~