?url_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Adc&rft.title=Redemptive+benefit+of+atorvastatin+in+the+risk+factors+of+coronary+artery+disease&rft.creator=Jayaraman+Gowri+%2C+Arumugam+Vijaya+Anand+%2C+Shanmugam+Achiraman+%2C+Govindha+Raj+Archunan+%2C+Subramaniyam+Kalavathy+%2C+Palanisamy+Sampath+Kumar++%2C+Kalaiyarasan+Vijaya+Kumar+Int+J+Cur+Biomed+Phar+Res.+&rft.subject=JOURNALS&rft.description=Cardiovascular+disease%2C+in+particular+coronary+artery+disease+(CAD)%2C+is+the+principal+cause+of+mortality+in+developed+countries.+The+++classical+++acute+++phase+++protein%2C+C-reactive+protein+(CRP)+is+an+exquisitely+sensitive+systemic+marker+of+disease+with+broad+clinical+utility+for+monitoring+and+differential+diagnosis.++In+recent+years%2C+acute+phase+reactants+have+been+shown+to+predict+future+cardiovascular+events+in+individuals+with+and+without+established+CAD.+Atorvastatin%2C+a+3-hydroxy-3-methylglutaryl+coenzyme+A+(HMG-CoA)+reductase+inhibitor%2C+substantially+reduce+cardiovascular+morbidity+and+mortality%2C+and+recently+their+anti-inflammatory+properties+have+been+investigated.++The+present+study+was+therefore+designed+to+determine+the+effects+of+atorvastatin+on+CRP+in+patients+with+CAD.++Ninety+two+patients+with+or+without+or+at+the+risk+of+CAD+were+recruited+for+the+study%2C+of+which+35+belongs+to+control+(untreated)+and+57+were+test+group%2C+in+which%2C+30+of+them+received+daily+with+20+mg%2Fday+of+atorvastatin+and+the+remaining+27+were+untreated.++The+patients+were+followed+for+over+a+period+of+6+weeks.++For+entire+study+population%2C+CRP+along+with+lipid+profile%2C+SGOT%2C+SGPT%2C+urea+and+creatinine+were+measured+1st+day+and+at+the+end+of+6th+week+of+the+treatment.++For+patients+with+or+at+risk+of+CAD%2C+the+reduced+rate+of+progression+of+atherosclerosis+associated+with+intensive+atorvastatin+treatment%2C+as+compared+with+control+is+significantly+related+to+greater+reduction+in+the+levels+of+both+atherogenic+lipoproteins+and+CRP.+This+may+be+important+with+respect+to+the+early+benefits+of+atorvastatin+therapy.&rft.publisher=CurrentSciDirect+Publications&rft.date=2011-04-30&rft.type=Journal+(Paginated)&rft.type=PeerReviewed&rft.format=application%2Fpdf&rft.identifier=http%3A%2F%2Fcogprints.org%2F7326%2F1%2FRedemptive_benefit_of_atorvastatin_in_the_risk_factors_of_coronary_artery_disease.pdf&rft.identifier=++Jayaraman+Gowri+%2C+Arumugam+Vijaya+Anand+%2C+Shanmugam+Achiraman+%2C+Govindha+Raj+Archunan+%2C+Subramaniyam+Kalavathy+%2C+Palanisamy+Sampath+Kumar+%2C+Kalaiyarasan+Vijaya+Kumar+Int+J+Cur+Biomed+Phar+Res.+++(2011)+Redemptive+benefit+of+atorvastatin+in+the+risk+factors+of+coronary+artery+disease.++%5BJournal+(Paginated)%5D+++++&rft.relation=http%3A%2F%2Fcogprints.org%2F7326%2F