creators_name: Mona Mlika, Zidi-Moaffak Y  , Lakhoua  Y, Farah  F, Kourda  N, Ben Abdallah  N, Zermani  R,  Baltagi-Ben Jilani  S , Int J Cur Bio Med Sci. 
creators_id: mlika.zorgati.mona@hotmail.com
type: journalp
datestamp: 2011-05-02 15:52:21
lastmod: 2011-05-02 15:52:21
metadata_visibility: show
title: About A Rare Cause Of Primary Hyperparathyroidism
ispublished: pub
subjects: JOURNALS
full_text_status: public
keywords: Clear cell hyperplasia, hyperparathyroidism, management
abstract: Introduction: Primary hyperparathyroïdism is observed in 35 to 44 subjects/ 100000 persons. The increased production of parathyroid hormones is secondary to primary glandular modifications consisting mainly in adenomas. The authors report a clear-cell hyperplasia causing primary hyperparathyroidism. Observation: We report the case of a 25-year-old man who was admitted to explore pathologic fractures of the left arm and a malignant hypercalcaemia. Complementary laboratory tests revealed primary hyperparathyroidism. A multiple endocrine neoplasia was excluded by radiologic examinations. Cervical ultra-sound examination revealed 2 parathyroid adenomas and per-operative exploration showed 3 « adenomas ». Microscopic examination of the 4 parathyroid glands specimen concluded to a clear cell hyperplasia.  Conclusion: Clear cell hyperplasia is a benign cause of primary hyperparathyroidism. The diagnosis is based upon histologic findings and examination of the 4 glands. 
date: 2011-04-30
date_type: published
publication: Int J Cur Bio Med Sci. 
volume: 1
number: 2
publisher: CurrentSciDirect Publications
pagerange: 47-48
refereed: TRUE
referencetext: [1]	Delellis A. Atlas of tumor pathology. Tumors of parathyroid gland. Washington DC: Armed Forces Institute of Pathology, 1993.
[2]	Bégueret H, Belleannée G, Dubrez J, Trouette H, Parrens M, Velly JF et al. Clear cell parathyroid adenoma : A rare and challenging lesion. Ann Pathol. 1999 ;19(4) :316-319.
[3]	Middleton LP, Merino MJ. The parathyroid glands. In: X. Head and Neck Surgical Pathology. Philadelphia: Lippincott Williams and Wilkins, 2001.
[4]	Lawrence DA. A histological comparison of adenomatous and hyperplastic parathyroid glands. J Clin Pathol.. 1978; 31:626-632.
[5]	Persson S, Hansson G, Hedman I, Tisell LE, Widéehn S. Primary parathyroid hyperplasia of water-clear cell type. Transformation of water-clear cells into chief cells. Acta Pathol Microbiol Immunol Scand. 1986; 94(6):391-395.




citation:   Mona Mlika, Zidi-Moaffak Y , Lakhoua Y, Farah F, Kourda N, Ben Abdallah N, Zermani R, Baltagi-Ben Jilani S , Int J Cur Bio Med Sci.   (2011) About A Rare Cause Of Primary Hyperparathyroidism.  [Journal (Paginated)]     
document_url: http://cogprints.org/7322/1/About_A_Rare_Cause_Of_Primary_Hyperparathyroidism.pdf