--- abstract: 'Tamsulosin is a sulfamoylphen-ethylamine derivative, a potent and a selective antagonist of Alpha-1A adrenoceptor. It�s approved in the treatment of LUTS in BPH disease, being a specific Alpha -1A blocker it does not interfere much with the cardiovascular system. Though an age old molecule but still it�s a friendly drug to most of the physicians. Even the recent studies found its as efficacious to some of the newer molecules in the group.' altloc: [] chapter: ~ commentary: ~ commref: ~ confdates: ~ conference: ~ confloc: ~ contact_email: ~ creators_id: - drpraveen28@gmail.com creators_name: - family: Praveen R given: 'Int J Cur Bio Med Sci. ' honourific: '' lineage: '' date: 2011-04-30 date_type: published datestamp: 2011-05-02 15:52:37 department: ~ dir: disk0/00/00/73/19 edit_lock_since: ~ edit_lock_until: 0 edit_lock_user: ~ editors_id: [] editors_name: [] eprint_status: archive eprintid: 7319 fileinfo: /style/images/fileicons/application_pdf.png;/7319/1/Tamsulosin_%EF%BF%BD_turn_a_round.pdf full_text_status: public importid: ~ institution: ~ isbn: ~ ispublished: pub issn: ~ item_issues_comment: [] item_issues_count: 0 item_issues_description: [] item_issues_id: [] item_issues_reported_by: [] item_issues_resolved_by: [] item_issues_status: [] item_issues_timestamp: [] item_issues_type: [] keywords: 'Tamsulosin, Alpha, Adrenoceptor' lastmod: 2011-05-02 15:52:37 latitude: ~ longitude: ~ metadata_visibility: show note: ~ number: 2 pagerange: 39-40 pubdom: TRUE publication: 'Int J Cur Bio Med Sci. ' publisher: CurrentSciDirect Publications refereed: TRUE referencetext: "[1]\tHieble JP, Bylund DB, Clarke DE. International union of pharmacology X. Recommendation for nomenclature of alpha-adrenoceptors: consensus update. J Pharmacol Rev 1994;47:267-270. \r\n[2]\tRoosen A, James B, Wood D, Fry C. Clinical and experimental aspects of Adreno-muscarinic synergy in the bladder base and prostate.2009;28(8):938-943.\r\n[3]\tPrice DT, Schwinn DA, Lomasney JW. Identification, quantification, and localization of mRNA for three distinct alpha-1 adrenergic receptor subtypes in human prostate.J Urol 1993;150:546-551\r\n[4]\tHoltgrewe HL. Current trends in management of men with lower urinary tract symptoms and benign prostatic hyperplasia. J Urol 1998;51:1-7.\r\n[5]\t Andersson KE. Mode of action of alpha-adrenoreceptor antagonists in the treatment of lower urinary tract symptoms. BJU 2000;85:12-18.\r\n[6]\tPuppo P. Do we know everything about alpha-blockade in the management of lower urinary tract symptoms?.J Eur Urol 2001;39:38-41.\r\n[7]\tSchwinn DA, Michelotti GA. alpha-Adrenergic receptors in the lower urinary tract and vascular bed: potential role for the alpha subtype in filling symptoms and effects of ageing on vascular expression. BJU 2000;85:6-11. \r\n[8]\tKhoury S, Cockett A, Aso Y. International consultation on urological diseases: a decade of progress. J Prostate 2000;45:194-199\r\n[9]\tPuppo P. Do we know everything about alpha-blockade in the management of lower urinary tract symptoms?. Eur Urol 2001 Jan; 39 Suppl. 2.: 38-41\r\n[10]\tBeduschi MC, Beduschi R, Oesterling JE. Alpha-blockade therapy for benign prostatic hyperplasia: from a nonselective to a more selective alpha1A-adrenergic antagonist. Urology 1998; 51: 861-72\r\n[11]\tde Mey C, Michel MC, McEwen J, et al. A double-blind comparison of terazosin and tamsulosin on their differential effects on ambulatory blood pressure and nocturnal orthostatic stress testing. Eur Urol 1998; 33: 481-8\r\n[12]\tvan Hoogdalem EJ, Soeishi Y, Matsushima H, et al. Disposition of the selective [alpha]1A-adrenoceptor antagonist tamsulosin in humans: comparison with data from interspecies scaling. J Pharm Sci 1997; 86: 1156-61\r\n[13]\tBoehringer Ingelheim Pharmaceuticals Incorporated. Flomax (tamsulosin) prescribing information. 2000.\r\n[14]\tSalinas F, Gabriela, Rosette J, Michel, Martin C. Pharmacokinetics and Pharmacodynamics of Tamsulosin in its Modified-Release and Oral Controlled Absorption System Formulations. 2010;49(3):177-88. \r\n[15]\tKawachi Y, Sakurai T, Sugimura S, Iwata S, Noto K, Honda S et al. Long-term treatment and prognostic factors of α1-blockers for lower urinary tract symptoms associated with benign prostatic hyperplasia: A pilot study comparing naftopidil and tamsulosin hydrochloride.2010;44:38-45.\r\n[16]\tYamanouchi Pharmaceutical Co. Ltd. Harnal (tamsulosin) prescribing information. 2000 \r\n\r\n" relation_type: [] relation_uri: [] reportno: ~ rev_number: 18 series: ~ source: ~ status_changed: 2011-05-02 15:52:37 subjects: - JOURNALS succeeds: ~ suggestions: ~ sword_depositor: ~ sword_slug: ~ thesistype: ~ title: Tamsulosin � turn a round type: journalp userid: 13352 volume: 1