?url_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Adc&rft.title=Inhibitory+effect+of+calotropis+gigantea+extract+on+ovalbumin-induced+airway+inflammation+and+arachidonic+acid+induced+inflammation+in+a+murine+model+of+asthma&rft.creator=Vipin+Bulani%2C+Kailash+Biyani%2C+Ravindra+Kale%2C+Unmesh+Joshi%2C+Kishor+Charhate%2C+Dinesh+Kumar%2C+Ramesh+Pagore%2C+Int+J+Cur+Bio+Med+Sci.+&rft.subject=JOURNALS&rft.description=The+root+of+Calotropis+gigantea+has+been+reported+as+a+traditional+folkloric+medicine+in+treatment+of+asthma+in+the+Indian+literature.+Root+contain+%CE%B1-and+%CE%B2-amyrin+are+reported+to+possess+anti-lipoxygenase+activity.+Present+study+was+undertaken+to+investigate+the+effect+of+methanolic+extract+of+root+of+Calotropis+gigantea+(Linn.)+R.Br.+(CG)+on+ovalbumin+induced+asthma+and+arachidonic+acid+induced+paw+edema+in+rats.+In+ovalbumin+induced+asthma%2C+rats+were+sensitized+and+challenged+with+ovalbumin+(OVA).+The+effect+of+CG+at+100%2C+200%2C+400+mg%2Fkg%2C+p.o.+on+inflammatory+cell+count%2C+level+of+nitric+oxide+and+total+protein+in+bronchalveolar+lavage+(BAL)+fluid%2C+lung+antioxidant+enzymes+(LPO%2C+GSH%2C+SOD%2C+Catalase)+and+histopathological+changes+were+observed.+Change+in+paw+edema+volume+was+measured+in+arachidonic+acid+induced+paw+edema+model.+CG+at+200%2C+400+mg%2Fkg%2C+p.o.+showed+significant+inhibition+of+eosinophil%2C+neutrophil+and+lymphocyte+and+total+leukocyte+count+in+bronchalveolar+lavage+(BAL)+fluid+(p%3C0.05).+In+BAL+fluid%2C+CG+significantly+reduced+the+nitric+oxide+and+total+protein+levels+(p%3C0.05).+CG+significantly+restored+the+levels+of+GSH%2C+SOD+and+LPO+in+lungs+(p%3C0.01).+CG+at+doses+of+200%2C+400+mg%2Fkg+significantly+inhibited+OVA+induced+histological+changes+(p%3C0.01).+CG+significantly+reduced+the+arachidonic+acid+induced+paw+edema+volume+(p%3C0.05).+These+results+suggest+that+CG+may+prove+to+be+potential+therapeutic+drug+for+treating+asthma+owing+to+its+anti-inflammatory%2C+anti-lipoxygenase+and+antioxidant+activities.++%0D%0A%0D%0A&rft.publisher=CurrentSciDirect+Publications&rft.date=2011-04-30&rft.type=Journal+(Paginated)&rft.type=PeerReviewed&rft.format=application%2Fpdf&rft.identifier=http%3A%2F%2Fcogprints.org%2F7315%2F1%2FInhibitory_effect_of_calotropis_gigantea_extract_on_ovalbumin-induced_airway_inflammation_and_arachidonic_acid_indu.pdf&rft.identifier=++Vipin+Bulani%2C+Kailash+Biyani%2C+Ravindra+Kale%2C+Unmesh+Joshi%2C+Kishor+Charhate%2C+Dinesh+Kumar%2C+Ramesh+Pagore%2C+Int+J+Cur+Bio+Med+Sci.+++(2011)+Inhibitory+effect+of+calotropis+gigantea+extract+on+ovalbumin-induced+airway+inflammation+and+arachidonic+acid+induced+inflammation+in+a+murine+model+of+asthma.++%5BJournal+(Paginated)%5D+++++&rft.relation=http%3A%2F%2Fcogprints.org%2F7315%2F