--- abstract: 'Rheumatoid arthritis (RA), a systemic autoimmune condition, causes joint damage and sometimes extra-articular lesions (cutaneous vasculitis, neuropathy, Felty’s syndrome, pericarditis, intersticial lung disease) that may be life threatening. The reason why extra-articular features will develop in rare RA patients is unknown. Our study was aimed to find any disease correlation with respect to a few genetic loci implicated in rheumatoid arthritis. In our study no significant association was observed for NFkB1 and MMP-1. However HLA-DRB1 showed polymorphism in RA and controls. The study was conducted on 60 patients, where 30 were control and 30 were diseased. All the patients selected for the study were RF (rheumatoid factor) positive. Therefore the studies need to be conducted on larger group of patients, so that the association can be verified in Caucasian population (Indian scenario).' altloc: [] chapter: ~ commentary: ~ commref: ~ confdates: ~ conference: ~ confloc: ~ contact_email: ~ creators_id: - shanuanupama@gmail.com creators_name: - family: 'Anupama Sharma, Ajay kumar Singh, Sanjeev kumar Singh' given: 'Int J Cur Sci Res. ' honourific: 'Neelima Singh, Varsha Gupta' lineage: '' date: 2011-04-30 date_type: published datestamp: 2011-05-02 15:53:49 department: ~ dir: disk0/00/00/73/05 edit_lock_since: ~ edit_lock_until: 0 edit_lock_user: ~ editors_id: [] editors_name: [] eprint_status: archive eprintid: 7305 fileinfo: /style/images/fileicons/application_pdf.png;/7305/1/Evolving_clinical_profile_of_HLA%2DDRB1%2C_MMP1_and_NF%2D%CE%9Ab_gene_in_rheumatoid_factor_positive_Caucasian_pop.pdf full_text_status: public importid: ~ institution: ~ isbn: ~ ispublished: pub issn: ~ item_issues_comment: [] item_issues_count: 0 item_issues_description: [] item_issues_id: [] item_issues_reported_by: [] item_issues_resolved_by: [] item_issues_status: [] item_issues_timestamp: [] item_issues_type: [] keywords: 'Rheumatoid arthritis, Rheumatoid factor, HLA-DRB1, MMP1, NFkB1. ' lastmod: 2011-05-02 15:53:49 latitude: ~ longitude: ~ metadata_visibility: show note: ~ number: 2 pagerange: 31-34 pubdom: TRUE publication: 'Int J Cur Sci Res. ' publisher: CurrentSciDirect Publications refereed: TRUE referencetext: "[1] Arnett FC, Edworthy SM, Bloch DA. The American Rheumatism Association 1987 revised criteria for the classification of rheumatoid arthritis. Arthritis Rheum. 1988; 31:315–24. \r\n[2] O Dell JR. Therapeutic Strategies for Rheumatoid Arthritis. N Engl J Med, 2004; 350:2591-2602.\r\n[3] Newton JL, Harney S M J, Wordsworth BP, Brown MA. A review of the MHC genetics of rheumatoid arthritis. Genes Immun. 2004; 5:151–157.\r\n[4] Gay S, Gay RE, Koopman WJ. Molecular and cellular mechanisms of joint destruction in rheumatoid arthritis: two cellular mechanisms explain joint destruction? Ann Rheum Dis. 1993; 52 Suppl 1:39-47.\r\n[5] Spurr NK, Gough AC, Gosden J, Rout D, Proteous DJ, Van H V, Docherty AJ. 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