?url_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Adc&rft.title=The+effects+of+sildenafil+ciltrate+on+the+lateral+geniculate+body+of+adult+Wistar+rats+(Rattus+norvegicus)-+A+histological+study&rft.creator=Eweka%2C+AO&rft.creator=Eweka%2C+A&rft.subject=Online+Journal+of+Health+and+Allied+Sciences&rft.description=The+histological+effect+of+oral+administration+of+sildenafil+citrate+(Viagra)%2C+commonly+used+as+an+aphrodisiac+and+for+the+treatment+of+erectile+dysfunction+on+one+of+the+visual+relay+centres+namely+the+lateral+geniculate+body+(LGB)+of+adult+Wistar+rat+was+carefully+studied.+The+rats+of+both+sexes+(n%3D24)%2C+average+weight+of+202g+were+randomly+assigned+into+three+treatment+(n%3D18)+and+control+(n%3D6)+groups.+The+rats+in+the+treatment+groups+%E2%80%98A%E2%80%99%2C+%E2%80%98B%E2%80%99+and+%E2%80%98C%E2%80%99+received+respectively%2C+0.25mg%2Fkg%2C+0.70mg%2Fkg+and+1.43mg%2Fkg+body+weight+of+sildenafil+citrate+base+dissolved+in+distilled+water+daily+for+30+days%2C+through+orogastric+feeding+tube%2C+while+that+of+the+control+group+D%2C+received+equal+volume+of+distilled+water+daily+during+the+period+of+the+experiment.+The+rats+were+fed+with+growers%E2%80%99+mash+obtained+from+Edo+Feeds+and+Flour+Mill+Ltd%2C+Ewu%2C+Edo+State%2C+Nigeria+and+were+given+water+liberally.+The+rats+were+sacrificed+on+day+thirty-one+of+the+experiment.+The+lateral+geniculate+body+(LGB)+was+carefully+dissected+out+and+quickly+fixed+in+10%25+formal+saline+for+histological+studies.+The+histological+findings+after+H%26E+method+indicated+that+the+treated+section+of+the+lateral+geniculate+body+(LGB)+showed+some+varying+degree+of+reduced+cellular+population+based+on+its+sparse+distribution%2C+degenerative+changes%2C+cellular+hypertrophy%2C+and+intercellular+vacuolations+appearing+in+the+stroma.+Varying+dosage+and+long+administration+of+sildenafil+citrate+may+have+some+deleterious+effects+on+the+neurons+of+the+intracranial+visual+relay+centre+and+this+may+probably+have+some+adverse+effects+on+visual+sensibilities+by+its+deleterious+effects+on+the+cells+of+the+lateral+geniculate+body+(LGB)+of+adult+Wistar+rats.+It+is+therefore+recommended+that+further+studies+aimed+at+corroborating+these+observations+be+carried+out.&rft.publisher=Dr.+B.S.+Kakkilaya&rft.contributor=Kakkilaya%2C+Dr+Srinivas&rft.date=2010-07-30&rft.type=Journal+(On-line%2FUnpaginated)&rft.type=PeerReviewed&rft.format=application%2Fpdf&rft.identifier=http%3A%2F%2Fcogprints.org%2F6994%2F1%2F2010-1-8.pdf&rft.identifier=++Eweka%2C+AO+and+Eweka%2C+A++(2010)+The+effects+of+sildenafil+ciltrate+on+the+lateral+geniculate+body+of+adult+Wistar+rats+(Rattus+norvegicus)-+A+histological+study.++%5BJournal+(On-line%2FUnpaginated)%5D+++++&rft.relation=http%3A%2F%2Fcogprints.org%2F6994%2F