creators_name: Bhagat, S creators_name: Varshney, S creators_name: Singh, R creators_name: Bist, SS creators_name: Gupta, N creators_id: sbent224@gmail.com editors_name: Kakkilaya, Srinivas editors_id: Kakkilaya BS type: journale datestamp: 2010-09-13 03:53:51 lastmod: 2011-03-11 08:57:42 metadata_visibility: show title: Malignant Melanoma of Nose and Paranasal Sinuses: 2 Case Reports ispublished: pub subjects: OJHAS full_text_status: public keywords: Malignant Melanoma, Nose, Paranasal sinuses abstract: Malignant melanoma is one of the rare and highly aggressive diseases of the sinonasal cavity. High index of suspicion is required for diagnosis as the patient usually presents with non specific signs and symptoms. In the natural course of the disease, higher rate of loco regional recurrences and distant metastasis are seen making the overall prognosis of disease very poor. In reviewing the various treatment modalities used in the past, surgical resection of the tumour with postoperative radiotherapy is preferred one. Advances in surgery, radiotherapy and chemotherapy don’t have any impact on improved survival, which remains poor in this disease. We report two cases of malignant melanoma, which were treated at our institute. date: 2010-04-30 date_type: published publication: Online Journal of Health and Allied Sciences volume: 8 number: 4 publisher: Dr. BS Kakkilaya refereed: TRUE referencetext: 1. Manolidis S, Donald PJ. Malignant mucosal melanoma of the head and neck: review of literature and report of 14 patients. Cancer 1997;80:1373-86. 2. Bridger AG, Smee D, Baldwin MAR et al. Experience with mucosal melanoma of the nose and paranasal sinuses. ANJ Surg. 2005;75:192-197. 3. Dwivedi R, Dwivedi R, Kazi R. Mucosal melanoma of nasal cavity and paranasal sinus: case report. J Cancer Res Ther. 2008;4:200-202. 4. Goldsmith HS, Melanoma: An overview. CA Cancer J Clin 1979;29:194-215. 5. McKinnon JG, Kokal WA, Neifeld JP et al. Natural history and treatment of mucosal melanoma. J Surg Oncol.1989;41:222-5. 6. Stern SJ, Guillamondegui OM, Mucosal melanoma of the head and neck. Head Neck 1991;13:22-7. 7. Sanderson AR, Gaylis B. Malignant melanoma of the sinonasal mucosa: Two case reports and review. ENT-Ear, Nose & Throat Journal. 2007;86:287-290. 8. Dauer HE, Lewis JE, Rohlinger LA et al. Sinonasal melanoma: A clinicopathological review of 61 cases. Otolaryngology-Head and neck Surgery: 2008; 238:347-352. 9. Volpe NJ, Albert DM. Metastatic and secondary orbital tumours. In Albert DM, Jackobeic FA, editors. Principles and practice of ophthalmology. 2nd ed. Phildelphia; W.B. Saunders. 2000. pp3218. 10. Chang AE, Karnell LH, Menck HR. The National Cancer Data Base report on cutaneous and noncutaneous melanoma: A summary of 84,836 cases from the past decade. The American college of Surgeons commission on Cancer and the American Cancer Society. Cancer. 1998;83(8):1664-78. 11. Temam S, Mamelle G, Marandas P, et al. Postaperative radiotherapy for primary mucosal melanomas of the head and neck. Cancer 2005;103:313-9. 12. Kingdom TT, Kaplan MJ. Mucosal melanoma of nasal cavity and paranasal sinuses. Head Neck 1995;17:184-9. citation: Bhagat, S and Varshney, S and Singh, R and Bist, SS and Gupta, N (2010) Malignant Melanoma of Nose and Paranasal Sinuses: 2 Case Reports. [Journal (On-line/Unpaginated)] document_url: http://cogprints.org/6985/1/2009-4-13.pdf