title: Total Thiols and MDA Levels in Patients with Acute Myocardial Infarction Before and After Reperfusion Therapy
creator: Babu, Suresh
creator: Shetty, Jeevan K
creator: Mungli, Prakash
subject: Online Journal of Health and Allied Sciences
description: Background: Reactive oxygen species have been implicated in the pathogenesis of ischemic and reperfusion injury. In the current work we have measured malondialdehyde (MDA), total thiols, total CK, CK-MB and AST in ECG proven acute myocardial infarction (AMI) patients immediately after admission and 24 hours after administration of thrombolytic agent streptokinase, and in healthy controls. Methods: Blood samples from 44 AMI patients and 25 age and sex matched healthy controls were obtained and analyzed for MDA, total thiols using spectrophotometric methods and cardiac enzymes CK, CK-MB and AST using automated analyzer. Results: We have found significant increase  in MDA, CPK, CK-MB, AST (p< 0.001) and significant decrease in total thiols (p<0.001) in AMI patients after thrombolytic therapy compared to values at admission, and healthy controls. MDA correlated negatively with total thiols (r = - 0.333, p<0.05) and positively with CK-MB (r = 0.491, p<0.01) in AMI patients after thrombolytic therapy. Conclusions: Reperfusion following thrombolytic therapy increases reactive oxygen species with concomitant decrease in antioxidant total thiols.
publisher: Dr. B.S. Kakkilaya
contributor: Kakkilaya, Dr Srinivas
date: 2010-10-15
type: Journal (On-line/Unpaginated)
type: PeerReviewed
format: application/pdf
identifier: http://cogprints.org/6978/1/2010-3-6.pdf
identifier:   Babu, Suresh and Shetty, Jeevan K and Mungli, Prakash  (2010) Total Thiols and MDA Levels in Patients with Acute Myocardial Infarction Before and After Reperfusion Therapy.  [Journal (On-line/Unpaginated)]     
relation: http://cogprints.org/6978/