?url_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Adc&rft.title=Total+Thiols+and+MDA+Levels+in+Patients+with+Acute+Myocardial+Infarction+Before+and+After+Reperfusion+Therapy&rft.creator=Babu%2C+Suresh&rft.creator=Shetty%2C+Jeevan+K&rft.creator=Mungli%2C+Prakash&rft.subject=Online+Journal+of+Health+and+Allied+Sciences&rft.description=Background%3A+Reactive+oxygen+species+have+been+implicated+in+the+pathogenesis+of+ischemic+and+reperfusion+injury.+In+the+current+work+we+have+measured+malondialdehyde+(MDA)%2C+total+thiols%2C+total+CK%2C+CK-MB+and+AST+in+ECG+proven+acute+myocardial+infarction+(AMI)+patients+immediately+after+admission+and+24+hours+after+administration+of+thrombolytic+agent+streptokinase%2C+and+in+healthy+controls.+Methods%3A+Blood+samples+from+44+AMI+patients+and+25+age+and+sex+matched+healthy+controls+were+obtained+and+analyzed+for+MDA%2C+total+thiols+using+spectrophotometric+methods+and+cardiac+enzymes+CK%2C+CK-MB+and+AST+using+automated+analyzer.+Results%3A+We+have+found+significant+increase++in+MDA%2C+CPK%2C+CK-MB%2C+AST+(p%3C+0.001)+and+significant+decrease+in+total+thiols+(p%3C0.001)+in+AMI+patients+after+thrombolytic+therapy+compared+to+values+at+admission%2C+and+healthy+controls.+MDA+correlated+negatively+with+total+thiols+(r+%3D+-+0.333%2C+p%3C0.05)+and+positively+with+CK-MB+(r+%3D+0.491%2C+p%3C0.01)+in+AMI+patients+after+thrombolytic+therapy.+Conclusions%3A+Reperfusion+following+thrombolytic+therapy+increases+reactive+oxygen+species+with+concomitant+decrease+in+antioxidant+total+thiols.&rft.publisher=Dr.+B.S.+Kakkilaya&rft.contributor=Kakkilaya%2C+Dr+Srinivas&rft.date=2010-10-15&rft.type=Journal+(On-line%2FUnpaginated)&rft.type=PeerReviewed&rft.format=application%2Fpdf&rft.identifier=http%3A%2F%2Fcogprints.org%2F6978%2F1%2F2010-3-6.pdf&rft.identifier=++Babu%2C+Suresh+and+Shetty%2C+Jeevan+K+and+Mungli%2C+Prakash++(2010)+Total+Thiols+and+MDA+Levels+in+Patients+with+Acute+Myocardial+Infarction+Before+and+After+Reperfusion+Therapy.++%5BJournal+(On-line%2FUnpaginated)%5D+++++&rft.relation=http%3A%2F%2Fcogprints.org%2F6978%2F