?url_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Adc&rft.title=A+Prospective+Analysis+of+Adverse+Drug+Reactions+in+a+South+Indian+Hospital&rft.creator=Padmaja%2C+U&rft.creator=Adhikari%2C+P&rft.creator=Pereira%2C+P&rft.subject=Online+Journal+of+Health+and+Allied+Sciences&rft.description=Adverse+drug+reactions+are+a+great+cause+of+concern+to+the+medical+profession%2C+the+patients+and+the+pharmaceutical+industry.+However+ADR+reporting+and+monitoring+is+yet+to+catch+up+in+India.+Hence+we+undertook+a+study+to+record+and+analyze+adverse+reactions+among+all+patients+admitted+to+the+medical+wards+of+a+tertiary+care.+Centre+patients+admitted+to+all+medical+wards+over+one+year+were+assessed+for+ADRs+throughout+their+admission.+Suspected+ADRs+were+recorded+and+analyzed+for+i)+the+type+of+reaction+ii)+severity+iii)+Consequence+on+treatment+that+is+if+the+drug+was+continued%2C+or+stopped%2C+or+needed+to+be+treated+with+other+drugs%2C+iv)+Physiological+system+involved+and+the+v)+group+of+the+drugs+associated+with+ADRs.+Among+1250+patients+admitted+during+the+study+period%2C+250+adverse+events+were+observed.+Majority+(76.8%25)+were+of+mild+type%2C+66%25+were+severe+requiring+intensive+care+and+3+patients+died.+Antimicrobials+were+responsible+for+maximum+(42.4%25)+ADRs+followed+by+drugs+acting+on+CNS+(20%25).+When+we+analyzed+the+systems+affected%2C+CNS+side+effects+were+more+common+in+our+study.+While+in+many+other+studies+Cardiovascular+and+gastrointestinal+side+effects+were+the+most+common.+Combination+of+drugs+was+responsible+for+a+large+percentage+of+ADRs.+Inadvertent+use+of+antipsychotics+with+sedatives+led+to+respiratory+failure+in+4+patients+of+which+1+died.+Contaminated+IV+fluids+are+suspected+to+be+the+cause+of+death+in+another+fatal+ADR.+In+conclusion+there+is+a+need+for+vigilant+ADR+monitoring+to+be+done+by+all+doctors+to+prevent+morbidity+and+mortality+from+ADRs.&rft.publisher=Dr.+BS+Kakkilaya&rft.contributor=Kakkilaya%2C+Dr+Srinivas&rft.date=2009-11-15&rft.type=Journal+(On-line%2FUnpaginated)&rft.type=PeerReviewed&rft.format=application%2Fpdf&rft.identifier=http%3A%2F%2Fcogprints.org%2F6959%2F1%2F2009-3-12.pdf&rft.identifier=++Padmaja%2C+U+and+Adhikari%2C+P+and+Pereira%2C+P++(2009)+A+Prospective+Analysis+of+Adverse+Drug+Reactions+in+a+South+Indian+Hospital.++%5BJournal+(On-line%2FUnpaginated)%5D+++++&rft.relation=http%3A%2F%2Fcogprints.org%2F6959%2F