?url_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Adc&rft.title=Total+Thiols%3A+Biomedical+Importance+And+Their+Alteration+In+Various+Disorders&rft.creator=Mungli%2C+Prakash&rft.creator=Shetty%2C+Mahesh+S&rft.creator=Tilak%2C+Prasiddha&rft.creator=Anwar%2C+Naureen&rft.subject=Online+Journal+of+Health+and+Allied+Sciences&rft.description=Thiols+are+the+organic+compounds+that+contain+a+sulphydryl+group.+Among+all+the+antioxidants+that+are+available+in+the+body%2C+thiols+constitute+the+major+portion+of+the+total+body+antioxidants+and+they+play+a+significant+role+in+defense+against+reactive+oxygen+species.+Total+thiols+composed+of+both+intracellular+and+extracellular+thiols+either+in+the+free+form+as+oxidized+or+reduced+glutathione%2C+or+thiols+bound+to+proteins.+Among+the+thiols+that+are+bound+to+proteins%2C+albumin+makes+the+major+portion+of+the+protein+bound+thiols%2C+which+binds+to+sufhydryl+group+at+its+cysteine-34+portion.+Apart+from+their+role+in+defense+against+free+radicals%2C+thiols+share+significant+role+in+detoxification%2C+signal+transduction%2C+apoptosis+and+various+other+functions+at+molecular+level.+The+thiol+status+in+the+body+can+be+assessed+easily+by+determining+the+serum+levels+of+thiols.+Decreased+levels+of+thiols+has+been+noted+in+various+medical+disorders+including+chronic+renal+failure+and+other+disorders+related+to+kidney%2C+cardiovascular+disorders%2C+stroke+and+other+neurological+disorders%2C+diabetes+mellitus%2C+alcoholic+cirrhosis+and+various+other+disorders.+Therapy+using+thiols+has+been+under+investigation+for+certain+disorders&rft.publisher=Kakkilaya+BS&rft.contributor=Kakkilaya%2C+Dr.+Srinivas&rft.date=2009-09-08&rft.type=Journal+(On-line%2FUnpaginated)&rft.type=PeerReviewed&rft.format=application%2Fpdf&rft.identifier=http%3A%2F%2Fcogprints.org%2F6664%2F1%2F2009-2-2.pdf&rft.identifier=++Mungli%2C+Prakash+and+Shetty%2C+Mahesh+S+and+Tilak%2C+Prasiddha+and+Anwar%2C+Naureen++(2009)+Total+Thiols%3A+Biomedical+Importance+And+Their+Alteration+In+Various+Disorders.++%5BJournal+(On-line%2FUnpaginated)%5D+++++&rft.relation=http%3A%2F%2Fcogprints.org%2F6664%2F