--- abstract: 'Glutamate is the major excitatory neurotransmitter in brain exerting prosurvival effect on neurons via N-methyl-D-aspartate receptor (NMDAR) signaling under physiological conditions. However in pathological circumstances such as ischemia, NMDARs might have proapoptotic excitotoxic activity. In contrast brain-derived neurotrophic factor (BDNF) signaling via TrkB receptors has been largely considered to promote neuronal differentiation, plasticity and survival during normal development, and protect neurons in pathophysiological conditions antagonizing the NMDAR-mediated excitotoxic cell death. In this review we summarize recent evidence for the existent crosstalk and positive feedback loops between the BDNF and NMDAR signaling and point out some of the important specific features of each signaling pathway.' altloc: [] chapter: ~ commentary: ~ commref: ~ confdates: ~ conference: ~ confloc: ~ contact_email: ~ creators_id: [] creators_name: - family: Georgiev given: Danko honourific: '' lineage: '' - family: Taniura given: Hideo honourific: '' lineage: '' - family: Kambe given: Yuki honourific: '' lineage: '' - family: Yoneda given: Yukio honourific: '' lineage: '' date: 2008-10-02 date_type: submitted datestamp: 2009-07-02 01:52:05 department: ~ dir: disk0/00/00/65/50 edit_lock_since: ~ edit_lock_until: ~ edit_lock_user: ~ editors_id: [] editors_name: - family: Chaldakov given: George honourific: '' lineage: '' eprint_status: archive eprintid: 6550 fileinfo: /style/images/fileicons/application_pdf.png;/6550/1/BMR_2008_19_17%2D27.pdf full_text_status: public importid: ~ institution: ~ isbn: ~ ispublished: pub issn: ~ item_issues_comment: [] item_issues_count: 0 item_issues_description: [] item_issues_id: [] item_issues_reported_by: [] item_issues_resolved_by: [] item_issues_status: [] item_issues_timestamp: [] item_issues_type: [] keywords: 'NMDA receptor, BDNF, neurotrophins' lastmod: 2011-03-11 08:57:22 latitude: ~ longitude: ~ metadata_visibility: show note: ~ number: ~ pagerange: 17-27 pubdom: FALSE publication: Biomedical Reviews publisher: Bulgarian Society for Cell Biology refereed: TRUE referencetext: "1.\tBlum R, Konnerth A. 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J Neurosci 2005; 25: 9535-9543.\r\n" relation_type: [] relation_uri: [] reportno: ~ rev_number: 26 series: ~ source: ~ status_changed: 2009-07-02 01:52:05 subjects: - neuro-pharm - neuro-physio - neuro-chem succeeds: ~ suggestions: 'This work was supported by the Japanese Ministry of Education, Culture, Sports, Science and Technology (MEXT) awarding the prestigious Monbukagakusho scholarship to Danko Georgiev for the period 10/2005-09/2008 and grants-in-aid for promotion of scientific research aided to Yukio Yoneda.' sword_depositor: ~ sword_slug: ~ thesistype: ~ title: Crosstalk Between Brain-Derived Neurotrophic Factor And N-Methyl-D-Aspartate Receptor Signaling In Neurons type: journalp userid: 3568 volume: 19