?url_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Adc&rft.title=Crosstalk+Between+Brain-Derived+Neurotrophic+Factor+And+N-Methyl-D-Aspartate+Receptor+Signaling+In+Neurons&rft.creator=Georgiev%2C+Danko&rft.creator=Taniura%2C+Hideo&rft.creator=Kambe%2C+Yuki&rft.creator=Yoneda%2C+Yukio&rft.subject=Neuropharmacology&rft.subject=Neurophysiology&rft.subject=Neurochemistry&rft.description=Glutamate+is+the+major+excitatory+neurotransmitter+in+brain+exerting+prosurvival+effect+on+neurons+via+N-methyl-D-aspartate+receptor+(NMDAR)+signaling+under+physiological+conditions.+However+in+pathological+circumstances+such+as+ischemia%2C+NMDARs+might+have+proapoptotic+excitotoxic+activity.+In+contrast+brain-derived+neurotrophic+factor+(BDNF)+signaling+via+TrkB+receptors+has+been+largely+considered+to+promote+neuronal+differentiation%2C+plasticity+and+survival+during+normal+development%2C+and+protect+neurons+in+pathophysiological+conditions+antagonizing+the+NMDAR-mediated+excitotoxic+cell+death.+In+this+review+we+summarize+recent+evidence+for+the+existent+crosstalk+and+positive+feedback+loops+between+the+BDNF+and+NMDAR+signaling+and+point+out+some+of+the+important+specific+features+of+each+signaling+pathway.&rft.publisher=Bulgarian+Society+for+Cell+Biology&rft.contributor=Chaldakov%2C+George&rft.date=2008-10-02&rft.type=Journal+(Paginated)&rft.type=PeerReviewed&rft.format=application%2Fpdf&rft.identifier=http%3A%2F%2Fcogprints.org%2F6550%2F1%2FBMR_2008_19_17-27.pdf&rft.identifier=++Georgiev%2C+Danko+and+Taniura%2C+Hideo+and+Kambe%2C+Yuki+and+Yoneda%2C+Yukio++(2008)+Crosstalk+Between+Brain-Derived+Neurotrophic+Factor+And+N-Methyl-D-Aspartate+Receptor+Signaling+In+Neurons.++%5BJournal+(Paginated)%5D+++++&rft.relation=http%3A%2F%2Fcogprints.org%2F6550%2F