?url_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Adc&rft.title=Evaluation+of+Buprenorphine+in+a+Postoperative%0D%0APain+Model+in+Rats&rft.creator=Curtin%2C+Dr.+Leslie+I.&rft.creator=Grakowsky%2C+Julie+A.&rft.creator=Suarez%2C+Mauricio&rft.creator=Thompson%2C+Dr.+Alexis+C.&rft.creator=DiPirro%2C+Dr.+Jean+M.&rft.creator=Martin%2C+Dr.+Lisa+B.E.&rft.creator=Kristal%2C+Dr.+Mark+B.&rft.subject=Psychobiology&rft.subject=Physiological+Psychology&rft.subject=Neuropharmacology&rft.subject=Behavioral+Neuroscience&rft.description=We+evaluated+the+commonly+prescribed+analgesic+buprenorphine+in+a+postoperative+pain+model+in+rats%2C+assessing+acute+postoperative+pain+relief%2C+rebound+hyperalgesia%2C+and+the+long-term+effects+of+postoperative+opioid+treatment+on+subsequent+opioid+exposure.+Rats+received+surgery+(paw+incision+under+isoflurane+anesthesia)%2C+sham+surgery+(anesthesia+only)%2C+or+neither+and+were+treated+postoperatively+with+1+of+several+doses+of+subcutaneous+buprenorphine.+Pain+sensitivity+to+noxious+and+nonnoxious+mechanical+stimuli+at+the+site+of+injury+(primary+pain)+was+assessed+at+1%2C+4%2C+24%2C+and+72+h+after+surgery.+Pain+sensitivity+at+a+site+distal+to+the+injury+(secondary+pain)+was+assessed+at+24+and+72+h+after+surgery.+Rats+were+tested+for+their+sensitivity+to+the+analgesic+and%0D%0Alocomotor+effects+of+morphine+9+to+10+d+after+surgery.+Buprenorphine+at+0.05+mg%2Fkg+SC+was+determined+to+be+the+most+effective%3B+this+dose+induced+isoalgesia+during+the+acute+postoperative+period+and+the+longest+period+of+pain+relief%2C+and+it+did+not+induce+longterm+changes+in+opioid+sensitivity+in+2+functional+measures+of+the+opioid+system.+A+lower+dose+of+buprenorphine+(0.01+mg%2Fkg+SC)+did+not+meet+the+criterion+for+isoalgesia%2C+and+a+higher+dose+(0.1+mg%2Fkg+SC)+was+less+effective+in+pain+relief+at+later+recovery+periods+and+induced+a+long-lasting+opioid+tolerance%2C+indicating+greater+neural+adaptations.+These+results+support+the+use+of+0.05+mg%2Fkg+SC+buprenorphine+as+the+upper+dose+limit+for+effective+treatment+of+postoperative+pain+in+rats+and+suggest+that+higher+doses+produce+long-term+effects+on+opioid+sensitivity.&rft.publisher=American+Association+for+Laboratory+Animal+Science&rft.date=2009&rft.type=Journal+(Paginated)&rft.type=PeerReviewed&rft.format=application%2Fpdf&rft.identifier=http%3A%2F%2Fcogprints.org%2F6399%2F1%2Fs7.pdf&rft.identifier=++Curtin%2C+Dr.+Leslie+I.+and+Grakowsky%2C+Julie+A.+and+Suarez%2C+Mauricio+and+Thompson%2C+Dr.+Alexis+C.+and+DiPirro%2C+Dr.+Jean+M.+and+Martin%2C+Dr.+Lisa+B.E.+and+Kristal%2C+Dr.+Mark+B.++(2009)+Evaluation+of+Buprenorphine+in+a+Postoperative+Pain+Model+in+Rats.++%5BJournal+(Paginated)%5D+++++&rft.relation=http%3A%2F%2Fcogprints.org%2F6399%2F