--- abstract: 'Amniotic fluid and placenta contain a substance (POEF) that when ingested enhances opioid-mediated analgesia produced by several agents (morphine injection, vaginal/cervical stimulation, late pregnancy, footshock), but not that produced by aspirin injection. The present series of experiments employed quaternary naltrexone, an opioid antagonist that does not readily cross the blood-brain barrier, in conjunction with either peripheral or central administration of morphine, to determine whether amniotic-fluid ingestion (and therefore POEF ingestion) enhances opioid-mediated analgesia by affecting the central and/or peripheral actions of morphine. The results suggest that POEF affects only the central analgesic effects of morphine.' altloc: [] chapter: ~ commentary: ~ commref: ~ confdates: ~ conference: ~ confloc: ~ contact_email: ~ creators_id: - dipirrjm@buffalostate.edu - athompso@ria.buffalo.edu - kristal@buffalo.edu creators_name: - family: DiPirro given: Jean M. honourific: '' lineage: '' - family: Thompson given: Alexis C. honourific: '' lineage: '' - family: Kristal given: Mark B. honourific: Dr. lineage: '' date: 1991 date_type: published datestamp: 2008-09-19 13:55:05 department: ~ dir: disk0/00/00/62/11 edit_lock_since: ~ edit_lock_until: ~ edit_lock_user: ~ editors_id: [] editors_name: [] eprint_status: archive eprintid: 6211 fileinfo: /style/images/fileicons/application_pdf.png;/6211/1/central.pdf full_text_status: public importid: ~ institution: ~ isbn: ~ ispublished: pub issn: ~ item_issues_comment: [] item_issues_count: 0 item_issues_description: [] item_issues_id: [] item_issues_reported_by: [] item_issues_resolved_by: [] item_issues_status: [] item_issues_timestamp: [] item_issues_type: [] keywords: 'POEF, analgesia, pain, rats, morphine, opioids, placenta, quaternary naltrexone, amniotic fluid, placentophagia, naltrexone methobromide' lastmod: 2011-03-11 08:57:12 latitude: ~ longitude: ~ metadata_visibility: show note: ~ number: 6 pagerange: 851-855 pubdom: TRUE publication: Brain Research Bulletin publisher: Pergamon Press refereed: TRUE referencetext: ~ relation_type: [] relation_uri: [] reportno: ~ rev_number: 29 series: ~ source: ~ status_changed: 2008-09-19 13:55:05 subjects: - psy-bio - physio-psy - neuro-pharm - behav-neuro-sci succeeds: ~ suggestions: ~ sword_depositor: ~ sword_slug: ~ thesistype: ~ title: "Amniotic-Fluid Ingestion Enhances the Central\r\nAnalgesic Effect of Morphine" type: journalp userid: 88 volume: 26