"6211","Amniotic-Fluid Ingestion Enhances the Central  Analgesic Effect of Morphine","Amniotic fluid and placenta contain a substance (POEF) that when ingested enhances opioid-mediated analgesia produced by several agents (morphine injection, vaginal/cervical stimulation, late pregnancy, footshock), but not that produced by aspirin injection. The present series of experiments employed quaternary naltrexone, an opioid antagonist that does not readily cross the blood-brain barrier, in conjunction with either peripheral or central administration of morphine, to determine whether amniotic-fluid ingestion (and therefore POEF ingestion) enhances opioid-mediated analgesia by affecting the central and/or peripheral actions of morphine. The results suggest that POEF affects only the central analgesic effects of morphine.","http://cogprints.org/6211/","DiPirro, Jean M. and Thompson, Alexis C. and Kristal, Dr. Mark B.","UNSPECIFIED","       <span class=\"person_name\">DiPirro, Jean M.</span> and <span class=\"person_name\">Thompson, Alexis C.</span> and <span class=\"person_name\">Kristal, Dr. Mark B.</span>     (1991)  <a href=\"http://cogprints.org/6211/\"><em>Amniotic-Fluid Ingestion Enhances the Central&#13; Analgesic Effect of Morphine.</em></a>       [Journal (Paginated)]           ","dipirrjm@buffalostate.edu,athompso@ria.buffalo.edu,kristal@buffalo.edu","1991"