title: Amniotic-Fluid Ingestion Enhances the Central  Analgesic Effect of Morphine
creator: DiPirro, Jean M.
creator: Thompson, Alexis C.
creator: Kristal, Dr. Mark B.
subject: Psychobiology
subject: Physiological Psychology
subject: Neuropharmacology
subject: Behavioral Neuroscience
description: Amniotic fluid and placenta contain a substance (POEF) that when ingested enhances opioid-mediated analgesia produced by several agents (morphine injection, vaginal/cervical stimulation, late pregnancy, footshock), but not that produced by aspirin injection. The present series of experiments employed quaternary naltrexone, an opioid antagonist that does not readily cross the blood-brain barrier, in conjunction with either peripheral or central administration of morphine, to determine whether amniotic-fluid ingestion (and therefore POEF ingestion) enhances opioid-mediated analgesia by affecting the central and/or peripheral actions of morphine. The results suggest that POEF affects only the central analgesic effects of morphine.
publisher: Pergamon Press
date: 1991
type: Journal (Paginated)
type: PeerReviewed
format: application/pdf
identifier: http://cogprints.org/6211/1/central.pdf
identifier:   DiPirro, Jean M. and Thompson, Alexis C. and Kristal, Dr. Mark B.  (1991) Amniotic-Fluid Ingestion Enhances the Central Analgesic Effect of Morphine.  [Journal (Paginated)]     
relation: http://cogprints.org/6211/