"6202","Hypoxia Inducible Factor-1α (HIF-1 α) and its Role in Tumour Progression to Malignancy","Hypoxia is a condition in which an area of the body or a tissue is deprived of sufficient supply of oxygen. The lack of nutrients in a hypoxic tissue generally causes apoptosis but some cells are able to adapt to this hypoxic environment and resist apoptosis. This adaptation occurs as a result of gene activation. Hypoxia is a characteristic feature of many cancers and is the stimulus for overexpression of HIF-1α - a basic loop-helix PAS protein family subunit of HIF, which allows the cell to adapt and survive in hostile environment. The presence of hypoxia and HIF-1α is correlated with an increased risk of metastasis and techniques that can inhibit hypoxia inducible factor may be instrumental in finding a cure for cancer","http://cogprints.org/6202/","Sharma, Gaurav Mrinal","Kakkilaya, Dr. Srinivas","       <span class=\"person_name\">Sharma, Gaurav Mrinal</span>     (2008)  <a href=\"http://cogprints.org/6202/\"><em>Hypoxia Inducible Factor-1α (HIF-1 α) and its Role in Tumour Progression to Malignancy.</em></a>       [Journal (On-line/Unpaginated)]           ","gauravmrinal@gmail.com","2008-07-21"