title: Hypoxia Inducible Factor-1α (HIF-1 α) and its Role in Tumour Progression to Malignancy
creator: Sharma, Gaurav Mrinal
subject: Online Journal of Health and Allied Sciences
description: Hypoxia is a condition in which an area of the body or a tissue is deprived of sufficient supply of oxygen. The lack of nutrients in a hypoxic tissue generally causes apoptosis but some cells are able to adapt to this hypoxic environment and resist apoptosis. This adaptation occurs as a result of gene activation. Hypoxia is a characteristic feature of many cancers and is the stimulus for overexpression of HIF-1α - a basic loop-helix PAS protein family subunit of HIF, which allows the cell to adapt and survive in hostile environment. The presence of hypoxia and HIF-1α is correlated with an increased risk of metastasis and techniques that can inhibit hypoxia inducible factor may be instrumental in finding a cure for cancer
publisher: Dr. B.S. Kakkilaya
contributor: Kakkilaya, Dr. Srinivas
date: 2008-07-21
type: Journal (On-line/Unpaginated)
type: PeerReviewed
format: application/pdf
identifier: http://cogprints.org/6202/1/2008-2-6.pdf
identifier:   Sharma, Gaurav Mrinal  (2008) Hypoxia Inducible Factor-1α (HIF-1 α) and its Role in Tumour Progression to Malignancy.  [Journal (On-line/Unpaginated)]     
relation: http://cogprints.org/6202/