@misc{cogprints6202,
          volume = {7},
          number = {2},
           month = {July},
          author = {Gaurav Mrinal Sharma},
          editor = {Dr. Srinivas Kakkilaya},
           title = {Hypoxia Inducible Factor-1{\ensuremath{\alpha}} (HIF-1 {\ensuremath{\alpha}}) and its Role in Tumour Progression to Malignancy},
       publisher = {Dr. B.S. Kakkilaya},
            year = {2008},
         journal = {Online Journal of Health and Allied Sciences},
        keywords = {HIF, HIF-1{\ensuremath{\alpha}}, Hypoxia, Malignancy, Cancer, Cancer Therapy},
             url = {http://cogprints.org/6202/},
        abstract = {Hypoxia is a condition in which an area of the body or a tissue is deprived of sufficient supply of oxygen. The lack of nutrients in a hypoxic tissue generally causes apoptosis but some cells are able to adapt to this hypoxic environment and resist apoptosis. This adaptation occurs as a result of gene activation. Hypoxia is a characteristic feature of many cancers and is the stimulus for overexpression of HIF-1{\ensuremath{\alpha}} - a basic loop-helix PAS protein family subunit of HIF, which allows the cell to adapt and survive in hostile environment. The presence of hypoxia and HIF-1{\ensuremath{\alpha}} is correlated with an increased risk of metastasis and techniques that can inhibit hypoxia inducible factor may be instrumental in finding a cure for cancer}
}

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