2008-09-19T13:59:25Z2011-03-11T08:57:11Zhttp://cogprints.org/id/eprint/6202This item is in the repository with the URL: http://cogprints.org/id/eprint/62022008-09-19T13:59:25ZHypoxia Inducible Factor-1α (HIF-1 α) and its Role in Tumour Progression to MalignancyHypoxia is a condition in which an area of the body or a tissue is deprived of sufficient supply of oxygen. The lack of nutrients in a hypoxic tissue generally causes apoptosis but some cells are able to adapt to this hypoxic environment and resist apoptosis. This adaptation occurs as a result of gene activation. Hypoxia is a characteristic feature of many cancers and is the stimulus for overexpression of HIF-1α - a basic loop-helix PAS protein family subunit of HIF, which allows the cell to adapt and survive in hostile environment. The presence of hypoxia and HIF-1α is correlated with an increased risk of metastasis and techniques that can inhibit hypoxia inducible factor may be instrumental in finding a cure for cancerGaurav Mrinal Sharmagauravmrinal@gmail.com