creators_name: Emokpae, MA creators_name: Nwokedi, EE creators_name: Jegede, EE creators_id: biodunemokpae@yahoo.com editors_name: Kakkilaya, Srinivas editors_id: Kakkilaya BS type: journale datestamp: 2008-09-19 13:59:53 lastmod: 2011-03-11 08:57:11 metadata_visibility: show title: Impact Of Hepatitis C Co-Infection On CD4 Cell Count In HIV Infected Subjects ispublished: pub subjects: OJHAS full_text_status: public keywords: Hepatitis C, Human Immunodeficiency virus, CD4 cell count, Co-infection abstract: Background: Human immunodeficiency virus (HIV) and Hepatitis C virus (HCV) co-infection is reported to be common among HIV infected subjects due to share routes of transmission. The fact that HCV infection may act as cofactor for HIV disease progression has been suggested. Objective: To determine if HCV and HIV co-infection affect the immunocompetence (CD4) of the infected subjects and response to Highly Active Anti Retroviral therapy. Subjects and methods: Fifty HIV/HCV co-infected and fifty HIV monoinfected adults were retrospectively studied. Their baseline CD4 cell counts were done using Dynal beads technique before commencement of HAART and repeated after six months. Results: The CD4 cell counts of co-infected subjects were lower than the mono-infected subjects. Sixty eight percent of the co-infected subjects had CD4 cell count less than 200cells/uL, and they responded poorly to HAART therapy than the mono-infected subjects (P<0.05). Those with CD4 cell count greater than 200cells/uL responded better to treatment than those with CD4 cell count less than 200cells/uL (P<0.001) Conclusion: HCV/HIV co-infection affects the immunocompetence of the patients and HCV may acts as cofactor for HIV disease progression. It is needful to screen all HIV positive subjects for HCV antibody as this will improve their clinical management and outcome. date: 2008-07-21 date_type: published publication: Online Journal of Health and Allied Sciences volume: 7 number: 2 publisher: Dr. B.S. Kakkilaya refereed: TRUE referencetext: 1. Nwokedi EE, Ilyasu Z, Emokpae MA, Dutse AI, Taura AA. Hepatitis C virus infection among Teaching Hospital patients in Kano, Nigeria: A Retrospective study. Annals Afri Med 2006;5(4):185-87 2. Bojuwole BJ. The burden of viral hepatitis in Africa. West Afri J Med 1997;16:198-203 3. Odama LE, Mohammed SE, Audu IG et al. Prevalence of Hepatitis C virus amongst HIV infected patients and blood donors in Nigeria. 4th National conference on HIV/AIDS in Nigeria, 2005. Abuja, Nigeria. 4. Ayodele OE, Salako BL. Hepatitis C virus and chronic renal disease. Afri J Med Sci 2003;32:287-291 5. Backus, LI Boothroyd, D Deyton, LR HIV,Hepatitis Cand HIV/hepatitis C virus co-infection in vulnerable populations. AIDS. 2005;19(3):S13-19 6. Vallet-Pichard A, Pol S. Hepatitis Viruses and HIV Co- infection: Pathogenesis and treatment. J Hepathol 2004;41(1):501-510 7. Soriano V, Puoti M, Bonacini M et al. Recommendations from an International Expert on Care of Patients with Chronic Hepatitis B and HIV Coinfection 2005; Internent Conference reports. 8. Akolo CO. Impact of Hepatitis B co-infection on the CD4 Cell counts of HIV/AIDS patients on Highly Active Anti Retroviral Therapy at the Jos University Teaching Hospital. 4th National Conference on HIV/AIDS in Nigeria, 2005. Abuja, Nigeria. 9. Salu O, Audu RA, Onyewuche JI, Idigbe EO. Profile of baseline viral load levels of newly diagnosed HIV-1 infected patients in Lagos, Nigeria. 4th National conference on HIV/AIDS in Nigeria. 2005 Abuja, Nigeria. citation: Emokpae, MA and Nwokedi, EE and Jegede, EE (2008) Impact Of Hepatitis C Co-Infection On CD4 Cell Count In HIV Infected Subjects. [Journal (On-line/Unpaginated)] document_url: http://cogprints.org/6199/1/2008-2-3.pdf