?url_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Adc&rft.title=Impact+Of+Hepatitis+C+Co-Infection+On+CD4+Cell+Count+In+HIV+Infected+Subjects&rft.creator=Emokpae%2C+MA&rft.creator=Nwokedi%2C+EE&rft.creator=Jegede%2C+EE&rft.subject=Online+Journal+of+Health+and+Allied+Sciences&rft.description=Background%3A+Human+immunodeficiency+virus+(HIV)+and+Hepatitis+C+virus+(HCV)+co-infection+is+reported+to+be+common+among+HIV+infected+subjects+due+to+share+routes+of+transmission.+The+fact+that+HCV+infection+may+act+as+cofactor+for+HIV+disease+progression+has+been+suggested.%0D%0AObjective%3A+To+determine+if+HCV+and+HIV+co-infection+affect+the+immunocompetence+(CD4)+of+the+infected+subjects+and+response+to+Highly+Active+Anti+Retroviral+therapy.%0D%0ASubjects+and+methods%3A+Fifty+HIV%2FHCV+co-infected+and+fifty+HIV+monoinfected+adults+were+retrospectively+studied.+Their+baseline+CD4+cell+counts+were+done+using+Dynal+beads+technique+before+commencement+of+HAART+and+repeated+after+six+months.%0D%0AResults%3A+The+CD4+cell+counts+of+co-infected+subjects+were+lower+than+the+mono-infected+subjects.+Sixty+eight+percent+of+the+co-infected+subjects+had+CD4+cell+count+less+than+200cells%2FuL%2C+and+they+responded+poorly+to+HAART+therapy+than+the+mono-infected+subjects+(P%3C0.05).+Those+with+CD4+cell+count+greater+than+200cells%2FuL+responded+better+to+treatment+than+those+with+CD4+cell+count+less+than+200cells%2FuL+(P%3C0.001)%0D%0AConclusion%3A+HCV%2FHIV+co-infection+affects+the+immunocompetence+of+the+patients+and+HCV+may+acts+as+cofactor+for+HIV+disease+progression.+It+is+needful+to+screen+all+HIV+positive+subjects+for+HCV+antibody+as+this+will+improve+their+clinical+management+and+outcome.&rft.publisher=Dr.+B.S.+Kakkilaya&rft.contributor=Kakkilaya%2C+Dr.+Srinivas&rft.date=2008-07-21&rft.type=Journal+(On-line%2FUnpaginated)&rft.type=PeerReviewed&rft.format=application%2Fpdf&rft.identifier=http%3A%2F%2Fcogprints.org%2F6199%2F1%2F2008-2-3.pdf&rft.identifier=++Emokpae%2C+MA+and+Nwokedi%2C+EE+and+Jegede%2C+EE++(2008)+Impact+Of+Hepatitis+C+Co-Infection+On+CD4+Cell+Count+In+HIV+Infected+Subjects.++%5BJournal+(On-line%2FUnpaginated)%5D+++++&rft.relation=http%3A%2F%2Fcogprints.org%2F6199%2F