?url_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Adc&rft.title=Interaction+between+cellular+retinoic+acid-binding+protein+II+and+histone+hypoacetylation+in+renal+cell+carcinoma&rft.creator=Wiwanitkit%2C+Viroj&rft.subject=Online+Journal+of+Health+and+Allied+Sciences&rft.description=Renal+cell+carcinoma+is+a+rare+but+serious+malignancy.+Since+a+reduction+in+the+level+of+retinoic+acid+receptor+beta+2+(RARbeta2)+expression+in+cancer+cells+due+in+part+to+histone+hypoacetylation+which+is+controlled+by+histone+deacetylase+(HD)%2C+the+study+on+the+interaction+between+cellular+retinoic+acid-binding+proteins+II+(CRABP+II)%2C+which+is+proposed+to+have+its+potential+influence+on+retinoic+acid+(RA)+response%2C+and+HD+can+be+useful.+Comparing+to+CARBP+II+and+HD%2C+the+CARBP+II-HD+poses+the+same+function+and+biological+process+as+HD.+This+can+confirm+that+HD+has+a+significant+suppressive+effect+on+the+expression+of+CARBP+II.+Therefore%2C+reduction+in+the+level+of+RARbeta2+expression+in+cancer+cells+can+be+expected+and+this+can+lead+to+failure+in+treatment+of+renal+cell+carcinoma+with+RA.+The+author+hereby+purpose+that+additional+HD+inhibitor+should+be+added+into+the+regiment+of+RA+to+increase+the+effectiveness+of+treatment.&rft.publisher=Dr.+B.S.+Kakkilaya&rft.contributor=Kakkilaya%2C+Dr.+Srinivas&rft.date=2008-04-10&rft.type=Journal+(On-line%2FUnpaginated)&rft.type=PeerReviewed&rft.format=application%2Fpdf&rft.identifier=http%3A%2F%2Fcogprints.org%2F6088%2F1%2F2008-1-7.pdf&rft.identifier=++Wiwanitkit%2C+Viroj++(2008)+Interaction+between+cellular+retinoic+acid-binding+protein+II+and+histone+hypoacetylation+in+renal+cell+carcinoma.++%5BJournal+(On-line%2FUnpaginated)%5D+++++&rft.relation=http%3A%2F%2Fcogprints.org%2F6088%2F