creators_name: Tarapacki, J. A.
creators_name: Thompson, A. C.
creators_name: Kristal, Mark B.
creators_id: 
creators_id: 
creators_id: kristal@buffalo.edu
type: journalp
datestamp: 2007-11-13 01:06:13
lastmod: 2011-03-11 08:56:59
metadata_visibility: show
title: Gastric vagotomy blocks opioid analgesia enhancement produced by placenta ingestion
ispublished: pub
subjects: physio-psy
subjects: behav-neuro-sci
subjects: neuro-chem
full_text_status: public
keywords: placenta, opioids, morphine, POEF, vagotomy, placentophagia, pain, analgesia, antinociception, tail-flick latency, vagus, rat
abstract: Ingestion of amniotic fluid or placenta by rats has been shown to enhance opioid-mediated analgesia induced by morphine injection, footshock, vaginal/cervical stimulation, or late pregnancy. This enhancement by ingestion appears to be specific to the central actions of opioids. The present study was designed to examine the possibility that information traveling via the vagus nerve might be involved in mediating this effect. Rats that had undergone either selective gastric vagotomy or sham vagotomy were injected with either morphine sulfate or vehicle and fed either placenta or a meat control. Enhancement was observed in rats that had undergone sham vagotomy but not in those that had undergone gastric vagotomy. These results support an interpretation of vagal involvement in the enhancement of opioid-mediated analgesia by placenta.
date: 1992
date_type: published
publication: Physiology & Behavior
volume: 52
number: 1
publisher: Pergamon Press
pagerange: 179-182
refereed: TRUE
citation:   Tarapacki, J. A. and Thompson, A. C. and Kristal, Dr. Mark B.  (1992) Gastric vagotomy blocks opioid analgesia enhancement produced by placenta ingestion.  [Journal (Paginated)]     
document_url: http://cogprints.org/5800/1/vagotomy.pdf