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dc:title "HTML Summary of #5771 \n\nPlacenta ingestion by rats enhances d- and k-opioid antinociception, but suppresses m-opioid antinociception\n\n";
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bibo:abstract "Ingestion of placenta or amniotic fluid produces a dramatic enhancement of centrally mediated opioid antinociception in the rat. The present experiments investigated the role of each opioid receptor type (m, d, k) in the antinociception-modulating effects of Placental Opioid-Enhancing Factor (POEF—presumably the active substance). Antinociception was measured on a 52 C hotplate in adult, female rats after they ingested placenta or control substance (1.0 g) and after they received an intracerebroventricular injection of a d-specific ([D-Pen2,D-Pen5]enkephalin (DPDPE); 0, 30, 50, 62, or 70 nmol), m-specific ([D-Ala2,N-MePhe4,Gly5-ol]enkephalin (DAMGO); 0, 0.21, 0.29, or 0.39 nmol), or k-specific\r\n(U-62066; spiradoline; 0, 100, 150, or 200 nmol) opioid receptor agonist. The results showed that ingestion of placenta potentiated d- and k-opioid antinociception, but attenuated m-opioid antinociception. This finding of POEF action as both opioid receptor-specific and complex\r\nprovides an important basis for understanding the intrinsic pain-suppression mechanisms that are activated during parturition and modified by placentophagia, and important information for the possible use of POEF as an adjunct to opioids in pain management."^^xsd:string;
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bibo:volume "1014";
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dct:date "2004";
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skos:prefLabel "Behavioral Neuroscience" .
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skos:prefLabel "Neuropharmacology" .
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skos:prefLabel "Psychobiology" .
foaf:name "Elsevier"^^xsd:string;
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foaf:familyName "DiPirro"^^xsd:string;
foaf:givenName "Jean M."^^xsd:string;
foaf:name "Jean M. DiPirro"^^xsd:string;
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foaf:familyName "Kristal"^^xsd:string;
foaf:givenName "Mark B."^^xsd:string;
foaf:name "Mark B. Kristal"^^xsd:string;
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