---
abstract: 'Amniotic fluid and placenta contain a substance (POEF, for Placental Opioid-Enhancing Factor) that, when ingested, enhances opioid-mediated analgesia in nonpregnant rats; ingestion of the substance by rats not experiencing opioid-mediated analgesia, however, does not produce analgesia. It is highly likely that periparturitional analgesia-enhancement is a significant benefit of ingestion of the afterbirth (placentophagia) during delivery. Here we report that prepartum ingestion of amniotic fluid (via orogastric infusion) does indeed enhance the endogenous-opioid-mediated analgesia evident at the end of pregnancy and during delivery; that the degree of enhancement is greater with 0.75 ml than with 0.25 ml, and that the prepartum enhancement of analgesia can be blocked with the opioid antagonist naloxone.'
altloc: []
chapter: ~
commentary: ~
commref: ~
confdates: ~
conference: ~
confloc: ~
contact_email: ~
creators_id:
  - kristal@buffalo.edu
  - ''
  - ''
  - ''
  - ''
  - ''
creators_name:
  - family: Kristal
    given: Mark B.
    honourific: Dr.
    lineage: ''
  - family: Thompson
    given: Alexis C.
    honourific: ''
    lineage: ''
  - family: Abbott
    given: P.
    honourific: ''
    lineage: ''
  - family: DiPirro
    given: Jean M.
    honourific: ''
    lineage: ''
  - family: Ferguson
    given: E.J.
    honourific: ''
    lineage: ''
  - family: Doerr
    given: J. C.
    honourific: ''
    lineage: ''
date: 1990
date_type: published
datestamp: 2007-10-22 10:44:38
department: ~
dir: disk0/00/00/57/69
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edit_lock_user: ~
editors_id: []
editors_name: []
eprint_status: archive
eprintid: 5769
fileinfo: /style/images/fileicons/application_pdf.png;/5769/1/ls.pdf
full_text_status: public
importid: ~
institution: ~
isbn: ~
ispublished: pub
issn: ~
item_issues_comment: []
item_issues_count: 0
item_issues_description: []
item_issues_id: []
item_issues_reported_by: []
item_issues_resolved_by: []
item_issues_status: []
item_issues_timestamp: []
item_issues_type: []
keywords: 'placentophagia, POEF, amniotic fluid, analgesia, pain, delivery, parturition, rat'
lastmod: 2011-03-11 08:56:59
latitude: ~
longitude: ~
metadata_visibility: show
note: ~
number: 10
pagerange: 693-698
pubdom: FALSE
publication: Life Sciences
publisher: Pergamon Press
refereed: TRUE
referencetext: ~
relation_type: []
relation_uri: []
reportno: ~
rev_number: 25
series: ~
source: ~
status_changed: 2007-10-22 10:44:37
subjects:
  - psy-bio
  - neuro-pharm
  - behav-neuro-sci
succeeds: ~
suggestions: ~
sword_depositor: ~
sword_slug: ~
thesistype: ~
title: Amniotic-fluid ingestion by parturient rats enhances pregnancy-mediated analgesia
type: journalp
userid: 88
volume: 46
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