TY  - GEN
ID  - cogprints5769
UR  - http://cogprints.org/5769/
A1  - Kristal, Dr. Mark B.
A1  - Thompson, Alexis C.
A1  - Abbott, P.
A1  - DiPirro, Jean M.
A1  - Ferguson, E.J.
A1  - Doerr, J. C.
Y1  - 1990///
N2  - Amniotic fluid and placenta contain a substance (POEF, for Placental Opioid-Enhancing Factor) that, when ingested, enhances opioid-mediated analgesia in nonpregnant rats; ingestion of the substance by rats not experiencing opioid-mediated analgesia, however, does not produce analgesia. It is highly likely that periparturitional analgesia-enhancement is a significant benefit of ingestion of the afterbirth (placentophagia) during delivery. Here we report that prepartum ingestion of amniotic fluid (via orogastric infusion) does indeed enhance the endogenous-opioid-mediated analgesia evident at the end of pregnancy and during delivery; that the degree of enhancement is greater with 0.75 ml than with 0.25 ml, and that the prepartum enhancement of analgesia can be blocked with the opioid antagonist naloxone.
PB  - Pergamon Press
KW  - placentophagia
KW  -  POEF
KW  -  amniotic fluid
KW  -  analgesia
KW  -  pain
KW  -  delivery
KW  -  parturition
KW  -  rat
TI  - Amniotic-fluid ingestion by parturient rats enhances pregnancy-mediated analgesia
SP  - 693
AV  - public
EP  - 698
ER  -

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