%A P. Abbott
%A A. C. Thompson
%A E.J. Ferguson
%A J. C. Doerr
%A J. A. Tarapacki
%A Dr. P.J. Kostyniak
%A J.A. Syracuse
%A D.M. Cartonia
%A Dr. Mark B. Kristal
%J Physiology & Behavior
%T Placental opioid-enhancing factor (POEF): Generalizability of effects
%X A substance in amniotic fluid and placenta (POEF for Placental Opioid-Enhancing Factor) has been shown to enhance opiate- or opioid-mediated analgesia in rats. Recent studies have only touched on the generalizability of the phenomenon. The present studies further tested the generalizability of the POEF effect: they examined sex specificity of the mechanism, whether POEF activity exists in afterbirth material of species other than the rat; whether POEF activity exists in tissue other than afterbirth material; whether POEF activity could be demonstrated after injection rather than ingestion of afterbirth material; and whether POEF enhances all opioid-mediated phenomena. We found that (a) POEF is effective in male rats as well as in female rats; (b) POEF activity exists in human and dolphin afterbirth material; (c) ingestion of pregnant-rat liver does not produce enhancement of opioid-mediated analgesia; (d) POEF does not seem to be effective when amniotic fluid is injected either IPO or SC; and (e) POEF does not modify morphine-induced hyperthermia.
%N 5
%K POEF, placenta, analgesia, opioids, amniotic fluid, pain, morphine, birth, placentophagia
%P 933-940
%V 50
%D 1991
%I Pergamon Press
%L cogprints5763

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